Genome Enhancer
Release 3.3 is now out!
Welcome to the new era of Precision Medicine
Meet Genome Enhancer – a fully automated pipeline for patient omics data analysis, which identifies prospective drug targets and corresponding treatments by reconstructing the molecular mechanism of the studied pathology. Proven applications of Genome Enhancer include cancer, neurodegenerative diseases, infectious diseases, diabetes and metabolic diseases, hypertension.
Genome Enhancer is also available as a part of TRANSFAC full package – a powerful synergism between the automatic pipeline for multi-omics data processing of Genome Enhancer and the comprehensive bioinformatics toolbox of the geneXplain® platform integrated with TRANSFAC, TRANSPATH, and HumanPSD databases. Find details on the TRANSFAC full package here.
In the first step of this analysis the transcription factors that regulate differentially expressed or mutated genes are identified with the use of the TRANSFAC® database of transcription factors binding sites.
The second step searches for common master-regulators of the identified transcription factors by building a personalized signal transduction network of the studied pathology using the TRANSPATH® database of mammalian signal transduction and metabolic pathways. The identified
master regulators are prospective drug target candidates. They are used for further selection of chemical compounds that can bring therapeutic benefit for the studied clinical case. In this step the HumanPSD™ database is employed to identify drugs that have been tested in clinical trials. The cheminformatic tool PASS predicts small molecules that can affect the identified targets.
Finally, Genome Enhancer generates a comprehensive analysis report about the personalized drug targets identified for a certain patient, or a group of patients, and the drugs that may be effective in this case. You can view a number of Genome Enhancer demo reports at the corresponding section of this page.
A detailed description of Genome Enhancer analysis schema can be found on this page.
Check out the Genome Enhancer video channel ran by the CSO of geneXplain GmbH Dr. Alexander Kel. See how various omics data can be analyzed in Genome Enhancer or even send your own data to Dr. Kel and he will show its analysis in one of the next videos!
