HumanPSD geneXplain

HumanPSD

The Human Proteome Survey Database (HumanPSD^TM) is a catalog of proteins and their complexes from human cells, plus their orthologs from mouse and rat sources.
Its main focus is on the association of human proteins with diseases as well as on their potential use as biomarkers.

Drugs targeting human proteins are reported. In addition, information can be retrieved on the molecular functions, biological roles, localization, and modifications of proteins, expression patterns across cells, tissues, organs, and tumors, consequences of gene mutations in mice, and the physical and regulatory interactions between proteins and genes. The TRANSPATH® database on signal transduction and metabolic pathways is an integral part of HumanPSD^TM.

Picture of HumanPSD

TP53_HumanPSD
Contents of a standard locus report of HumanPSD

Introduction
Description
Synonyms

Biomarker Associations
Diseases associated with MYC
Inherit MYC mutations

Drug Interactions
Drug(s) targeting MYC

Gene Ontology
Molecular function
Biological process
Cellular component

Expression
Tissue expression

Regulation of MYC expression

Mutant Phenotype

Mutant phenotype of closely related homolog(s)

Pathways & interactions
Pathways
Protein-protein interactions
Events acting on MYC
Events triggered by MYC

Transcriptional Regulation
Add a subscription to TRANSFAC® and this report will display additional information

RNA Features
Overview of RNA sequence

Protein Features
Overview of protein sequence and structure
Post-translational modifications of MYC protein
View complex containing MYC protein

Identifiers
Accessions mapped to this record

Annotations
Description
Editor’s Notes
Disease related

Biomarker / disease associations

A tabular summary of literature-derived relationships between human genes and gene products with human diseases is given.

These associations are clearly sorted according to their type, e.g. whether a gene/protein has a causal relationship with a disease to develop, or whether it is merely correlative, etc.

Tabulated summary of disease associations of the human MYC gene.

Key features

Reports about more than 53,000 proteins and 5000 microRNAs.

More than 120,000 gene-disease assignments extracted from original scientific literature and evaluated by experts, referring to more than 3,900 diseases (human) or disease models (mouse).

More than 45,000 drug-protein interactions, referring to more than 9,200 drugs.

More than 600,000 assignments to Gene Ontology (GO), manually annotated and quality-checked.

More than 2,361,000 gene expression assignments.

More than 958,000 annotation statements given.

More than 370,000 references to peer-reviewed scientific publications provided.

An integrated Ontology Browser supports easy selection of defined sets of gene/molecules.

A tool for functional analysis allows to identify shared characteristics in a set of genes/proteins or miRNAs.

TRANSPATH included!

Benefits

Quickly access detailed reports for individual genes, proteins, miRNAs, diseases,
and drugs without time-consuming literature search.

Uncover biologically relevant connections between seemingly disparate genes,
diseases, and drugs.

Identify and rank potential therapeutic targets based on known functional
characteristics.

Explore canonical pathways and build custom protein networks, overlaying
known disease and drug associations.

Videos

Drug report and pathway report in HumanPSD+TRANSPATH® – this video demonstrates how drug report looks like in the online interface of HumanPSD+TRANSPATH® database. Target molecules, corresponding to a particular drug, are demonstrated, and pathways, in which these molecules are involved, are shown in a very detailed way, with all the underlying reactions, from which the corresponding pathways are constructed. Clinical trials info is also shown for each particular drug and for certain cases even metabolizing enzymes and associated pathways info is also available.

Disease report overview in HumanPSD+TRANSPATH® – this video demonstrates how disease report looks like in the online interface of HumanPSD+TRANSPATH® database. Disease biomarkers are shown (genes or proteins or miRNAs) with the type of association and type of indication info. All respective references are demonstrated. Disease similarity maps are also shown (these maps are based on the similarity of different diseases in respect to the common biomarkers that they share).

Disease similarity maps by common biomarkers in HumanPSD+TRANSPATH® – this video shows the overview of disease similarity maps. Common biomarkers of different diseases are displayed on these schemas. The searched disease is placed in the center of the map. The maps have the following color code: diseases sharing common biomarkers are connected with red lines; diseases that have ontological relationships according to the MeSH ontology are connected by gray lines.