GERONTOSHIELD

GERONTOSHIELD – Systems biology-driven approach to unravel and revert the mechanisms responsible for poor immune responses in the elderly
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A collaborative project funded by the German Federal Ministry of Education and Research (BMBF) in the funding program “Systems Biology for Health in the Old Age – GerontoSys2”

Coordinator:
The project is coordinated by Prof. Dr. Carlos Guzmán, Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany. The 6 participants of the consortium are from Braunschweig, Jena, Martinsried, Regensburg, Tübingen, and Wolfenbüttel.

  • Contract period: February 1st, 2011 – January 31st, 2014
  • Grant no.: FKZ0315890B
  • Summary:

The strategic objective of the GERONTOSHIELD project is to draw on a Systems Biology-driven approach to understand the molecular processes affected during immunosenescence, in order to derive (i) global mathematical models describing the involved processes, (ii) a holistic model for flu infections in young and elderly, and (iii) strategies to overcome these processes to establish immune interventions tailored for the elderly.

Further information:
Homepage of GERONTOSHIELD
Press release of the Helmholtz Centre for Infection Research (HZI; in German)
Press release of the Helmholtz Centre for Infection Research (HZI; in English)

Publications:
Wingender, E. (2013) Criteria for an updated classification of human transcription factor DNA-binding domains. J. Bioinform. Comput. Biol. 11, 1340007. doi: 10.1142/S0219720013400076. Link
Wingender, E., Schoeps, T., Dönitz, J. (2013) TFClass: An expandable hierarchical classification of human transcription factors. Nucleic Acids Res. 41, D165-D170. doi: 10.1093/nar/gks1123. Link

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