Signaling and metabolic pathways information


Receive access to one of the largest available, manually curated, pathway databases containing more than 1,090,000 reactions..

For each of the 190 pathways contained in TRANSPATH database, you will find explicit information on the pathway subcomponents and individual reactions, from which the pathway subcomponent was assembled:

IFNalpha:beta pathway

All reactions are supported by experimental details and respective references.

Pathway/Chain Report – presents information about pathways and chains involved in signaling or metabolism.

Reaction Report – presents information about the individual reactions that comprise signaling and metabolic pathways.

The database also contains the protein-protein interactions (PPIs) information, as well as information of post-translational modifications (PTMs):

protein-protein interactions

Example locus report with this and other information can be downloaded here or viewed below:

Locus Report BRCA1 (BRCA1) , Human


PathFinder pathway visualization and modification tool


PathFinder is the tool for visualization of signaling and metabolic pathways. It is an integrative part of the TRANSPATH database.

The PathFinder tab automatically opens in your browser after you have selected to visualize any of the pathways in the geneXplain portal interface by clicking on the PathFinder link:


PathFinder launch


Upon opening any pathway from the geneXplain portal interface in the PathFinder, you will see two diagrams:
One will be automatically layouted in respect to the intracellular compartments its elements belong to:


Pathway with compartments visualization example


And the other one will not contain compartments and will be subject to user-selected layout in the tools menu:


Pathway without compartments visualization example


All PathFinder diagrams without compartments have a standard SBGN and SBML operations menu (toolbar) available on the top of the diagram:


SBGN and SBML operations menu (toolbar)


This menu allows adding new elements to the currently opened diagram. The blank field on the right side of the toolbar is a search input window. It can be used for searching for certain elements in the currently opened diagram. The search term should be submitted in the format of MO ID (e.g. ErbB1 ID: MO000016681). Enter the needed MO ID in the blank field and press Enter. If the currently opened diagram contains the respective element, the diagram will be repositioned on the screen in such a way that the searched element will be placed in the center of the main PathFinder window.
You will find further details on the PathFinder tool in its User Guide.