miRCol
Identification of miRNA-transcription factor network motifs to search for drug repurposing candidates in the treatment of colorectal liver metastasis
This project is funded by the German-Russian Funding Competition in the Area of Industry-Oriented Applied Research and Cooperation of Innovative SMEs 2016
GeneXplain’s contribution to the project is in
- scanning available relevant data to identify miRNAs;
- determining promoter and enhancer regions for genes related to CRC / CLM;
- developing advanced algorithms to find common TF regulatory sites in miRNA and CRC / CLM genes;
- integrating these results with miRNA target predictions using bioinformatic resources;
- reconstructing combined TF and miRNA regulatory networks of CRC / CLM genes;
- establishing a reference protein-protein interaction database for CRC / CLM genes;
- finding TFs in feed-forward loops (FFL), which are also highly represented in the CRC / CLM PPI database;
- detecting possible drug attack points by modeling the FFLs;
- selecting drug candidates.