The program contains a knowledgebase with more than 14 thousand of known interactions between biological activities, as well as the relationships between proteins, signalling / regulatory pathways (KEGG, Reactome), Gene Ontology biological processes and therapeutic and adverse effects.
All biological activities are divided onto 7 types: (1) mechanisms of action; (2) pharmacological effects; (3) toxic and side effects; (4) interaction with antitargets; (5) interaction with drug metabolizing enzymes (inhibition, induction, interaction as a substrate); (6) interaction with transporter protein (inhibition, stimulation, interaction as a substrate); (7) changing gene expression of individual genes (increase, decrease).
Analysis of possible drug-drug interactions is performed simultaneously for all 7 types of biological activity.
Automatic search for compounds acting on any of the mechanisms of action (or simultaneously on several mechanisms of action, up to 10) associated with the therapeutic effect or signalling/regulatory pathway (KEGG, Reactome) or biological process of Gene Ontology.
User-friendly interface, fast download speed and analysis of the prediction results of PASS, PASS Affinity and GUSAR.
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