PROTEOME™ (HumanPSD™+TRANSPATH®) release 2018.2
The Human Proteome Survey Database (HumanPSDTM) with focus on human proteins as disease biomarkers and drug targets contains these new data features:
- Increased number of interventions in clinical trials mapped to drugs
New data from clinicaltrials.gov and manual curation by experts has increased the number of Clinical Trial-Drug assignments to 172,962.
A shift in curation to yet underrepresented neoplasms (such as mouth or esophageal cancer) in the database has increased the number of gene – disease assignments to 110,961.
The TRANSPATH® database on mammalian signal transduction and metabolic pathways contains these new data features:
- Human phosphatases interactome
5,412 new or updated reactions detailing the interactome and substrates of human phosphatases from recent publications.
57,890 reactions have been added or updated with additional experimental evidence by incorporating the BioPlex 2.0 network of human protein interactions.
Thank you very much for your interest in our programs!
Please contact us and you will be provided with your free trial version.
The basic information unit is a “locus report”, which summarizes the existing knowledge about the product(s) of a gene. It is part of a hierarchy, with individual proteins (isoforms such as splice variants) encoded by a gene at a level under the locus report, and summarizing features of the orthologs of human, mouse and rat origin at a higher level.
HumanPSDTM Statistics 2018.2 (download)
HumanPSDTM Features 2018.2 (download)
HumanPSDTM Release and Statistics 2018.1 (download)
HumanPSD FlyerTM (download)
Stegmaier, P., Krull, M., Voss, N., Kel, A.E., Wingender, E. (2010) Molecular mechanistic associations of human diseases. BMC Syst Biol. 4, 124. doi: 10.1186/1752-0509-4-124. PubMed.
Michael, H., Hogan, J., Kel, A., Kel-Margoulis, O., Schacherer, F., Voss, N., Wingender, E. (2008) Building a knowledge base for systems pathology. Brief. Bioinform. 9, 518-531. doi: 10.1093/bib/bbn038. PubMed.
Wingender, E., Crass, T., Hogan, J.D., Kel, A.E., Kel-Margoulis, O.V., Potapov, A.P. (2007) Integrative content-driven concepts for bioinformatics “beyond the cell”. J Biosci. 32, 169-180. PubMed.
Hodges PE, Carrico, P.M., Hogan, J.D., O’Neill, K.E., Owen, J.J., Mangan, M., Davis, B.P., Brooks, J.E., Garrels, J.I. (2002) Annotating the human proteome: the Human Proteome Survey Database (HumanPSD) and an in-depth target database for G protein-coupled receptors (GPCR-PD) from Incyte Genomics. Nucleic Acids Res. 30:137-141. PubMed.
HumanPSD is a trademark of QIAGEN GmbH.