HumanPSD

HumanPSDTM release 2017.2 is available now

The Human Proteome Survey Database (HumanPSDTM) is a catalog of proteins and their complexes from human cells, plus their orthologs from mouse and rat sources.
Its main focus is on the association of human proteins with diseases as well as on their potential use as biomarkers.

Drugs targeting human proteins are reported. In addition, information can be retrieved on the molecular functions, biological roles, localization, and modifications of proteins, expression patterns across cells, tissues, organs, and tumors, consequences of gene mutations in mice, and the physical and regulatory interactions between proteins and genes. The TRANSPATH® database on signal transduction and metabolic pathways is an integral part of HumanPSDTM.

Picture of HumanPSD

Contents of a standard locus report of HumanPSD
Introduction

  • Description
  • Synonyms
Biomarker Associations

  • Diseases associated with MYC
  • Inherit MYC mutations
Drug Interactions

Drug(s) targeting MYC

Gene Ontology

  • Molecular function
  • Biological process
  • Cellular component
Expression

  • Tissue expression
  • Regulation of MYC expression
Mutant Phenotype

Mutant phenotype of closely related homolog(s)

Pathways & interactions

  • Pathways
  • Protein-protein interactions
  • Events acting on MYC
  • Events triggered by MYC
Transcriptional Regulation
Add a subscription to TRANSFAC® and this report will display additional information
RNA Features

Overview of RNA sequence

Protein Features

  • Overview of protein sequence and structure
  • Post-translational modifications of MYC protein
  • View complex containing MYC protein
Identifiers

  • Accessions mapped to this record
Annotations

  • Description
  • Editor’s Notes
  • Disease related

Biomarker / disease associations

A tabular summary of literature-derived relationships between human genes and gene products with human diseases is given.
These associations are clearly sorted according to their type, e.g. whether a gene/protein has a causal relationship with a disease to develop, or whether it is merely correlative, etc.
Disease association MYC

Tabulated summary of disease associations of the human MYC gene.

Key features

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Reports about more than 53,000 proteins and 4,500 microRNAs.
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More than 110,000 gene-disease assignments extracted from original scientific literature and evaluated by experts,
referrring to more than 4000 diseases (human)/disease models (mouse).
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More than 14,000 drug-protein interactions, referring to more than 8,200 drugs.
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More than 580,000 assignments to Gene Ontology (GO), manually annotated and quality-checked.
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More than 461,000 gene expression assignments.
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More than 936,000 annotation statements given.
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More than 381,000 references to peer-reviewed scientific publications provided.
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An integrated Ontology Browser supports easy selection of defined sets of gene/molecules.
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TRANSPATH included! Comprehensive pathway information allows easy connection between molecules, diseases and pathways affected.

Benefits

Quickly access detailed reports for individual genes, proteins, miRNAs, diseases,
and drugs without time-consuming literature search.
Uncover biologically relevant connections between seemingly disparate genes,
diseases, and drugs.
Identify and rank potential therapeutic targets based on known functional
characteristics.
Explore canonical pathways and build custom protein networks, overlaying
known disease and drug associations.

New release

HumanPSD™+ TRANSPATH® (PROTEOME™) release 2017.2

 

The Human Proteome Survey Database (HumanPSDTM) with focus on human proteins as disease biomarkers and drug targets contains these new data features:

  • Integration of new data on clinical trials (Increase of CT-Disease-Drug assignments from 146,605 to 227,170 due to inclusion of new data as well as improved mapping)

The TRANSPATH® database on mammalian signal transduction and metabolic pathways contains these new data features:

  • 4,589 additional miRNA family entries according to TargetScanHuman release 7.1, allowing the transformation of 24,488 miRNA–target gene reactions from experimental evidence to semantic level

Free trial

Thank you very much for your interest in our programs!

Please contact us and you will be provided with your free trial version.

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Reports

The basic information unit is a “locus report”, which summarizes the existing knowledge about the product(s) of a gene. It is part of a hierarchy, with individual proteins (isoforms such as splice variants) encoded by a gene at a level under the locus report, and summarizing features of the orthologs of human, mouse and rat origin at a higher level.

Publications

Stegmaier, P., Krull, M., Voss, N., Kel, A.E., Wingender, E. (2010) Molecular mechanistic associations of human diseases. BMC Syst Biol. 4, 124. doi: 10.1186/1752-0509-4-124. PubMed.

Michael, H., Hogan, J., Kel, A., Kel-Margoulis, O., Schacherer, F., Voss, N., Wingender, E. (2008) Building a knowledge base for systems pathology. Brief. Bioinform. 9, 518-531. doi: 10.1093/bib/bbn038. PubMed.

Wingender, E., Crass, T., Hogan, J.D., Kel, A.E., Kel-Margoulis, O.V., Potapov, A.P. (2007) Integrative content-driven concepts for bioinformatics “beyond the cell”. J Biosci. 32, 169-180. PubMed.

Hodges PE, Carrico, P.M., Hogan, J.D., O’Neill, K.E., Owen, J.J., Mangan, M., Davis, B.P., Brooks, J.E., Garrels, J.I. (2002) Annotating the human proteome: the Human Proteome Survey Database (HumanPSD) and an in-depth target database for G protein-coupled receptors (GPCR-PD) from Incyte Genomics. Nucleic Acids Res. 30:137-141. PubMed.

HumanPSD is a trademark of QIAGEN GmbH.

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