PROTEOME™ (HumanPSD™+TRANSPATH®) release 2018.1
The Human Proteome Survey Database with focus on human proteins as disease biomarkers and drug targets contains these new data features:
- Improved biomarker retrieval from disease reports
Biomarkers can be retrieved by type of association with the disease or by indication for the utility of the biomarker, matching the categories of the biomarker association table in a disease report. The sets of biomarkers can be exported or used as input for the PathwayBuilder visualization tool or processed by other tools.
- Increased number of conditions in clinical trials mapped to diseases
New data from clinicaltrials.gov and manual curation by experts has increased the number of Clinical Trial-Disease assignments to 664,258, leading to 362,881 CT-Disease-Drug assignments.
The TRANSPATH® database on mammalian signal transduction and metabolic pathways contains these new data features:
- Cancer pathway list
The canonical signal transduction pathway overview page now contains a section for pathways involved in the development of various types of cancer.
Thank you very much for your interest in our programs!
Please contact us and you will be provided with your free trial version.
The basic information unit is a “locus report”, which summarizes the existing knowledge about the product(s) of a gene. It is part of a hierarchy, with individual proteins (isoforms such as splice variants) encoded by a gene at a level under the locus report, and summarizing features of the orthologs of human, mouse and rat origin at a higher level.
HumanPSDTM Release and Statistics 2018.1 (download)
HumanPSDTM Statistics 2017.3 (download)
HumanPSDTM Features 2017.3 (download)
HumanPSD FlyerTM (download)
Stegmaier, P., Krull, M., Voss, N., Kel, A.E., Wingender, E. (2010) Molecular mechanistic associations of human diseases. BMC Syst Biol. 4, 124. doi: 10.1186/1752-0509-4-124. PubMed.
Michael, H., Hogan, J., Kel, A., Kel-Margoulis, O., Schacherer, F., Voss, N., Wingender, E. (2008) Building a knowledge base for systems pathology. Brief. Bioinform. 9, 518-531. doi: 10.1093/bib/bbn038. PubMed.
Wingender, E., Crass, T., Hogan, J.D., Kel, A.E., Kel-Margoulis, O.V., Potapov, A.P. (2007) Integrative content-driven concepts for bioinformatics “beyond the cell”. J Biosci. 32, 169-180. PubMed.
Hodges PE, Carrico, P.M., Hogan, J.D., O’Neill, K.E., Owen, J.J., Mangan, M., Davis, B.P., Brooks, J.E., Garrels, J.I. (2002) Annotating the human proteome: the Human Proteome Survey Database (HumanPSD) and an in-depth target database for G protein-coupled receptors (GPCR-PD) from Incyte Genomics. Nucleic Acids Res. 30:137-141. PubMed.
HumanPSD is a trademark of QIAGEN GmbH.