HumanPSD™+TRANSPATH® release 2020.1
The Human Proteome Survey Database (HumanPSDTM) with focus on human proteins as disease biomarkers and drug targets contains these new features:
• External disease identifiers added
External identifiers and hyperlinks to disease classifications and ontologies such as ICD10, Snomed CT or NCI thesaurus have been included based on data from the Mondo Disease Ontology and the Disease Ontology (DO).
In total, 26,615 external references have been added to 2,817 distinct disease reports.
• More Clinical Trial and Biomarker data
New data from clinicaltrials.gov and manual disease biomarker curation by experts have increased the number of CT-Disease-Drug assignments to 424,169 and the number of disease annotations to 333,184.
The TRANSPATH® database on mammalian signal transduction and metabolic pathways contains these new data features:
• Increase in number of reactions
1,450 new binding reactions between proteins in human and in mouse have been added, among them e.g. reactions of the human KRAB zinc finger protein or the mouse GAP/GEF protein interactome.
Thank you very much for your interest in our programs!
Please contact us and you will be provided with your free trial version.
The basic information unit is a “locus report”, which summarizes the existing knowledge about the product(s) of a gene. It is part of a hierarchy, with individual proteins (isoforms such as splice variants) encoded by a gene at a level under the locus report, and summarizing features of the orthologs of human, mouse and rat origin at a higher level.
HumanPSDTM Statistics (download)
HumanPSDTM Features (download)
HumanPSD FlyerTM (download)
Stegmaier, P., Krull, M., Voss, N., Kel, A.E., Wingender, E. (2010) Molecular mechanistic associations of human diseases. BMC Syst Biol. 4, 124. doi: 10.1186/1752-0509-4-124. PubMed.
Michael, H., Hogan, J., Kel, A., Kel-Margoulis, O., Schacherer, F., Voss, N., Wingender, E. (2008) Building a knowledge base for systems pathology. Brief. Bioinform. 9, 518-531. doi: 10.1093/bib/bbn038. PubMed.
Wingender, E., Crass, T., Hogan, J.D., Kel, A.E., Kel-Margoulis, O.V., Potapov, A.P. (2007) Integrative content-driven concepts for bioinformatics “beyond the cell”. J Biosci. 32, 169-180. PubMed.
Hodges PE, Carrico, P.M., Hogan, J.D., O’Neill, K.E., Owen, J.J., Mangan, M., Davis, B.P., Brooks, J.E., Garrels, J.I. (2002) Annotating the human proteome: the Human Proteome Survey Database (HumanPSD) and an in-depth target database for G protein-coupled receptors (GPCR-PD) from Incyte Genomics. Nucleic Acids Res. 30:137-141. PubMed.
HumanPSD is a trademark of QIAGEN GmbH.