HumanPSD™ release 2022.1
The Human Proteome Survey Database (HumanPSDTM) with focus on human proteins as disease biomarkers and drug targets contains these new features:
- Quantitative tissue expression diagram in human locus reports
Normalized transcript expression levels from Human Protein Atlas (v20) are displayed in a histogram across 61 different cell types / tissues. There are several sorting and grouping options, e.g. cell/tissue by organ. In addition, a value for the relative tissue specificity as indicator for expression ubiquity of the respective human gene is given.
- Extended options to use search results as input for further queries
The added options include the possibilities to query for drugs approved or under research for a certain condition from a search result of diseases and vice versa.
- Biomarker and drug target data update
The number of disease annotations increased to 369,215 and the number of unique gene/biomarker – disease assignments to 126,804. Targets for FDA – approved drugs have been added by manual curation and the number of drug – target protein associations is now 51,827.
The basic information unit is a “locus report”, which summarizes the existing knowledge about the product(s) of a gene. It is part of a hierarchy, with individual proteins (isoforms such as splice variants) encoded by a gene at a level under the locus report, and summarizing features of the orthologs of human, mouse and rat origin at a higher level.
HumanPSDTM Statistics (download)
HumanPSDTM Features (download)
HumanPSD FlyerTM (download)
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HumanPSD is a trademark of QIAGEN GmbH.