PROTEOME™ (HumanPSD™+TRANSPATH®) release 2019.2
The Human Proteome Survey Database (HumanPSD™) with focus on human proteins as disease
biomarkers and drug targets contains these new features:
- More Clinical Trial data
New data from clinicaltrials.gov and manual curation by experts have increased the number
of Clinical Trial-Drug assignments to 204,740, leading to a total of 401,836 CT-Disease-Drug
- GO cellular compartment annotation from the Human Protein Atlas
Intracellular location data of human proteins from the Human Protein Atlas has been
integrated as 12,073 observations using Gene Ontology Cellular Compartment terms.
The TRANSPATH® database on mammalian signal transduction and metabolic pathways contains
these new data features:
- Increase in numbers of reactions
18,087 new binding reactions between proteins in human or mouse have been added,
among them e.g. reactions of membrane-bound human GPCRs with other membraneous or
5,071 existing reactions were updated with additional experimental evidences from primary
- Improved pathway search results
Pathway search results now come with the number of distinct nodes (proteins and their
post-translationally modified forms, genes, miRNAs, and complexes) involved in the
respective pathway. This should help with assessing the size of networks in a result list.
Thank you very much for your interest in our programs!
Please contact us and you will be provided with your free trial version.
The basic information unit is a “locus report”, which summarizes the existing knowledge about the product(s) of a gene. It is part of a hierarchy, with individual proteins (isoforms such as splice variants) encoded by a gene at a level under the locus report, and summarizing features of the orthologs of human, mouse and rat origin at a higher level.
HumanPSDTM Statistics 2019.2 (download)
HumanPSDTM Features 2019.2 (download)
HumanPSDTM Statistics 2019.1 (download)
HumanPSDTM Features 2019.1 (download)
HumanPSDTM Statistics 2018.3 (download)
HumanPSDTM Features 2018.3 (download)
HumanPSDTM Release and Statistics 2018.1 (download)
HumanPSD FlyerTM (download)
Stegmaier, P., Krull, M., Voss, N., Kel, A.E., Wingender, E. (2010) Molecular mechanistic associations of human diseases. BMC Syst Biol. 4, 124. doi: 10.1186/1752-0509-4-124. PubMed.
Michael, H., Hogan, J., Kel, A., Kel-Margoulis, O., Schacherer, F., Voss, N., Wingender, E. (2008) Building a knowledge base for systems pathology. Brief. Bioinform. 9, 518-531. doi: 10.1093/bib/bbn038. PubMed.
Wingender, E., Crass, T., Hogan, J.D., Kel, A.E., Kel-Margoulis, O.V., Potapov, A.P. (2007) Integrative content-driven concepts for bioinformatics “beyond the cell”. J Biosci. 32, 169-180. PubMed.
Hodges PE, Carrico, P.M., Hogan, J.D., O’Neill, K.E., Owen, J.J., Mangan, M., Davis, B.P., Brooks, J.E., Garrels, J.I. (2002) Annotating the human proteome: the Human Proteome Survey Database (HumanPSD) and an in-depth target database for G protein-coupled receptors (GPCR-PD) from Incyte Genomics. Nucleic Acids Res. 30:137-141. PubMed.
HumanPSD is a trademark of QIAGEN GmbH.