FREE

FREE resources from geneXplain

 

GeneXplain is providing the best-in-class bioinformatics tools for various research applications to its customers. Besides that we fully support the idea of openness and availability of information to the scientific community and for this reason we are proud to share with you a variety of great tools and valuable information resources that were made publicly available by us for free regardless of your occupation and research interests.
We wish you good luck in your research!

 

INFORMATION  RESOURCES

 

Classification of Human Transcription Factors

Classification of Human Transcription Factors (TFclass)

Free download TFClass descriptions

 

Search for a transcription factor (TF)

Free search for a transcription factor within the TRANSFAC factor table

 

ENDONET

ENDONET: List of messengers/hormones and their receptors

Extracted from the EndoNet database, the list exhibits numerous ligand-receptor pairs, including their links to EndoNet, UniProt and HumanPSD.

Learn more:
Dönitz, J. and Wingender, E. (2014) EndoNet: an information resource about the intercellular signaling network.
BMC Syst Biol. 8, 49. Link

and go here to the full list.

 

Disease similarity maps

The HumanPSD™ harbors one of the largest human disease biomarker databases with over 123,000 gene-disease assignments curated from the scientific literature. The detailed information encompasses a classification of biomarkers into four classes, Causal, Correlative, Negative and Preventative, that indicate a biomarker gene’s role in the associated disease. The disease similarity maps depict inferred disease-disease relationships on the basis of shared causal biomarker genes, with the preventative biomarkers subsumed. A disease network derived from these relationships organized disease entities into clusters with apparent biomedical relevance. Furthermore, several of the inferred associations coincided with known clinical correlations such as comorbidities or known disease etiologies (details).

Open geneXplain disease similarity maps

 

 

TOOLS

 

 

eBioMeCon

eBioMeCon: embedding of BioMedical Concepts

Identify related biomedical concepts (diseases, drugs, genes, pathways).

To learn more, see:

Alachram, H., Chereda, H., Beißbarth, T., Wingender, E., Stegmaier. P. (2021) Text mining-based word representations for biomedical data analysis and protein-protein interaction networks in machine learning tasks.
PLoS One 16, e0258623. Link

and go here to the tool.

 

ProTargetMiner

ProTargetMiner – a proteome signature library of anticancer molecules for functional discovery.

To learn more, see:

Saei, A.A., Beusch, C.M., Chernobrovkin, A. et al. ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery. Nat Commun 10, 5715 (2019). Link

and go here to the tool.

 

ProteoTracker

ProteoTracker is a free tool for studying of cell type transitions. This web-based visualization tool allows studying of such transitions by simultaneous measurement of protein expression and thermal stability changes in cells. Such detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine.

To learn more, see:

Sabatier, P., Beusch, C.M., Saei, A.A. et al. An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation. Nat Commun12, 6558 (2021). Link

and go here to the tool.

 

EDUCATIONAL WEBINARS

 

GeneXplain is holding free educational webinars devoted to various aspects of biomedical research and gene regulation studies.

Our recent World Cancer Research Day 2021 at geneXplain event has gathered many scientists, researchers and students interested in the gene regulation changes that lead to emergence and progression of cancer in various cancer patients. The video records or some sessions are available at the event page.

For news about our upcoming webinars and video records of the already held ones please refer to the FREE WEBINARS page of our web site.

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