GeneXplain Disease Similarity Maps

October 15, 2021

The HumanPSD™ harbors one of the largest human disease biomarker databases with over 123,000 gene-disease assignments curated from the scientific literature. The detailed information encompasses a classification of biomarkers into four classes, Causal, Correlative, Negative and Preventative, that indicate a biomarker gene's role in the associated disease. The similarity maps linked to the disease on this page depict inferred disease-disease relationships on the basis of shared causal biomarker genes, with the preventative biomarkers subsumed. A disease network derived from these relationships organized disease entities into clusters with apparent biomedical relevance. Furthermore, several of the inferred associations coincided with known clinical correlations such as comorbidities or known disease etiologies (details).


Disease Similarity Map Disease Report in HumanPSD™
(requires subscription)
Abnormalities, Multiple Abnormalities, Multiple map DI000009487
Acidosis Acidosis map DI000010802
Acquired Immunodeficiency Syndrome Acquired Immunodeficiency Syndrome map DI000007339
Acrocephalosyndactylia Acrocephalosyndactylia map DI000009042
Acromegaly Acromegaly map DI000008818
Adenocarcinoma Adenocarcinoma map DI000007654
Adenoma Adenoma map DI000008950
Adrenal Cortex Diseases Adrenal Cortex Diseases map DI000010095
Adrenal Cortex Neoplasms Adrenal Cortex Neoplasms map DI000008077
Adrenal Gland Diseases Adrenal Gland Diseases map DI000008071
Adrenal Gland Neoplasms Adrenal Gland Neoplasms map DI000009844
Adrenal Hyperplasia, Congenital Adrenal Hyperplasia, Congenital map DI000007887
Adrenal Insufficiency Adrenal Insufficiency map DI000009105
Adrenoleukodystrophy Adrenoleukodystrophy map DI000007980
AIDS Dementia Complex AIDS Dementia Complex map DI000007080
Albinism Albinism map DI000008151
Albinism, Oculocutaneous Albinism, Oculocutaneous map DI000007707
Alzheimer Disease Alzheimer Disease map DI000010597
Amenorrhea Amenorrhea map DI000007099
Amino Acid Metabolism, Inborn Errors Amino Acid Metabolism, Inborn Errors map DI000008294
Amyloidosis Amyloidosis map DI000009341
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis map DI000009630
Anemia Anemia map DI000010107
Anemia, Hemolytic Anemia, Hemolytic map DI000011038
Anemia, Hemolytic, Congenital Anemia, Hemolytic, Congenital map DI000007813
Anemia, Sickle Cell Anemia, Sickle Cell map DI000010971
Aneurysm Aneurysm map DI000010042
Angina Pectoris Angina Pectoris map DI000007075
Aniridia Aniridia map DI000007882
Ankylosis Ankylosis map DI000008852
Anorexia Nervosa Anorexia Nervosa map DI000011159
Antiphospholipid Syndrome Antiphospholipid Syndrome map DI000008973
Aortic Stenosis, Subvalvular Aortic Stenosis, Subvalvular map DI000008853
Aortic Valve Stenosis Aortic Valve Stenosis map DI000007108
Arrhythmias, Cardiac Arrhythmias, Cardiac map DI000010330
Arrhythmogenic Right Ventricular Dysplasia Arrhythmogenic Right Ventricular Dysplasia map DI000007669
Arterial Occlusive Diseases Arterial Occlusive Diseases map DI000007467
Arteriosclerosis Arteriosclerosis map DI000009444
Arthritis Arthritis map DI000010997
Arthritis, Juvenile Arthritis, Juvenile map DI000008420
Arthritis, Psoriatic Arthritis, Psoriatic map DI000009531
Arthritis, Rheumatoid Arthritis, Rheumatoid map DI000010109
Asthma Asthma map DI000010033
Astrocytoma Astrocytoma map DI000010804
Ataxia Ataxia map DI000008123
Ataxia Telangiectasia Ataxia Telangiectasia map DI000009227
Atherosclerosis Atherosclerosis map DI000015794
Atrial Fibrillation Atrial Fibrillation map DI000010408
Autoimmune Diseases Autoimmune Diseases map DI000010232
Autoimmune Diseases of the Nervous System Autoimmune Diseases of the Nervous System map DI000007647
Bacterial Infections Bacterial Infections map DI000009111
Bardet-Biedl Syndrome Bardet-Biedl Syndrome map DI000009397
Bartter Syndrome Bartter Syndrome map DI000009453
Basal Ganglia Diseases Basal Ganglia Diseases map DI000009566
Behcet Syndrome Behcet Syndrome map DI000009622
Bile Duct Neoplasms Bile Duct Neoplasms map DI000009007
Biliary Tract Neoplasms Biliary Tract Neoplasms map DI000008933
Bipolar Disorder Bipolar Disorder map DI000011120
Blindness Blindness map DI000009365
Blood Coagulation Disorders Blood Coagulation Disorders map DI000009240
Blood Coagulation Disorders, Inherited Blood Coagulation Disorders, Inherited map DI000009791
Blood Platelet Disorders Blood Platelet Disorders map DI000008627
Bone Diseases Bone Diseases map DI000010861
Bone Diseases, Developmental Bone Diseases, Developmental map DI000008564
Bone Diseases, Metabolic Bone Diseases, Metabolic map DI000007735
Bone Marrow Diseases Bone Marrow Diseases map DI000010706
Bone Neoplasms Bone Neoplasms map DI000008198
Brain Diseases Brain Diseases map DI000009854
Brain Diseases, Metabolic Brain Diseases, Metabolic map DI000007093
Brain Diseases, Metabolic, Inborn Brain Diseases, Metabolic, Inborn map DI000010384
Brain Infarction Brain Infarction map DI000008341
Brain Ischemia Brain Ischemia map DI000009826
Brain Neoplasms Brain Neoplasms map DI000008346
Breast Neoplasms Breast Neoplasms map DI000010422
Bronchial Neoplasms Bronchial Neoplasms map DI000010460
Burkitt Lymphoma Burkitt Lymphoma map DI000010888
Carbohydrate Metabolism, Inborn Errors Carbohydrate Metabolism, Inborn Errors map DI000008885
Carcinoma Carcinoma map DI000007794
Carcinoma, Basal Cell Carcinoma, Basal Cell map DI000009788
Carcinoma, Bronchogenic Carcinoma, Bronchogenic map DI000010799
Carcinoma, Ductal, Breast Carcinoma, Ductal, Breast map DI000008239
Carcinoma, Endometrioid Carcinoma, Endometrioid map DI000010884
Carcinoma, Hepatocellular Carcinoma, Hepatocellular map DI000007071
Carcinoma, Non-Small-Cell Lung Carcinoma, Non-Small-Cell Lung map DI000010366
Carcinoma, Pancreatic Ductal Carcinoma, Pancreatic Ductal map DI000007290
Carcinoma, Papillary Carcinoma, Papillary map DI000009859
Carcinoma, Renal Cell Carcinoma, Renal Cell map DI000007479
Carcinoma, Small Cell Carcinoma, Small Cell map DI000008265
Carcinoma, Squamous Cell Carcinoma, Squamous Cell map DI000007187
Cardiomegaly Cardiomegaly map DI000008136
Cardiomyopathies Cardiomyopathies map DI000008761
Cardiomyopathy, Dilated Cardiomyopathy, Dilated map DI000007962
Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic map DI000008105
Cardiovascular Diseases Cardiovascular Diseases map DI000008856
Carotid Artery Diseases Carotid Artery Diseases map DI000010762
Celiac Disease Celiac Disease map DI000010614
Central Nervous System Diseases Central Nervous System Diseases map DI000010292
Central Nervous System Neoplasms Central Nervous System Neoplasms map DI000010637
Cerebellar Ataxia Cerebellar Ataxia map DI000010950
Cerebellar Diseases Cerebellar Diseases map DI000009063
Cerebral Small Vessel Diseases Cerebral Small Vessel Diseases map DI000030892
Cerebrovascular Disorders Cerebrovascular Disorders map DI000008137
Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Disease map DI000008626
Cholangiocarcinoma Cholangiocarcinoma map DI000007192
Chorea Chorea map DI000007926
Chromosome Disorders Chromosome Disorders map DI000010467
Coagulation Protein Disorders Coagulation Protein Disorders map DI000010521
Cognition Disorders Cognition Disorders map DI000011137
Colitis Colitis map DI000008316
Colitis, Ulcerative Colitis, Ulcerative map DI000010561
Collagen Diseases Collagen Diseases map DI000007627
Coloboma Coloboma map DI000009841
Colonic Neoplasms Colonic Neoplasms map DI000007503
Colorectal Neoplasms Colorectal Neoplasms map DI000007849
Congenital Abnormalities Congenital Abnormalities map DI000008605
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities map DI000008680
Connective Tissue Diseases Connective Tissue Diseases map DI000009390
Coronary Artery Disease Coronary Artery Disease map DI000007879
Coronary Disease Coronary Disease map DI000010362
Coronavirus Infections Coronavirus Infections map DI000008578
Craniofacial Abnormalities Craniofacial Abnormalities map DI000010463
Crohn Disease Crohn Disease map DI000007866
Cushing Syndrome Cushing Syndrome map DI000009488
Cystic Fibrosis Cystic Fibrosis map DI000009073
Cysts Cysts map DI000010640
Deafness Deafness map DI000010465
Death, Sudden Death, Sudden map DI000009192
Dementia Dementia map DI000008114
Demyelinating Diseases Demyelinating Diseases map DI000010926
Dermatitis Dermatitis map DI000010512
Dermatitis, Atopic Dermatitis, Atopic map DI000009517
Diabetes Complications Diabetes Complications map DI000009926
Diabetes Mellitus Diabetes Mellitus map DI000007890
Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 1 map DI000008515
Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 map DI000008516
Diabetic Angiopathies Diabetic Angiopathies map DI000010539
Diabetic Nephropathies Diabetic Nephropathies map DI000010827
Disorder of Sex Development, 46,XY Disorder of Sex Development, 46,XY map DI000030032
Disorders of Sex Development Disorders of Sex Development map DI000009982
DNA Virus Infections DNA Virus Infections map DI000007564
Dry Eye Syndromes Dry Eye Syndromes map DI000009597
Dwarfism Dwarfism map DI000009623
Dyskinesias Dyskinesias map DI000007230
Dyslipidemias Dyslipidemias map DI000015793
Dystonia Dystonia map DI000010825
Ear Diseases Ear Diseases map DI000007442
Ectodermal Dysplasia Ectodermal Dysplasia map DI000010951
Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome map DI000010397
End Stage Liver Disease End Stage Liver Disease map DI000030062
Endocrine System Diseases Endocrine System Diseases map DI000010416
Endometrial Neoplasms Endometrial Neoplasms map DI000008647
Epilepsies, Myoclonic Epilepsies, Myoclonic map DI000009173
Epilepsies, Partial Epilepsies, Partial map DI000009025
Epilepsy Epilepsy map DI000007491
Epilepsy, Generalized Epilepsy, Generalized map DI000011060
Epileptic Syndromes Epileptic Syndromes map DI000033303
Epstein-Barr Virus Infections Epstein-Barr Virus Infections map DI000008567
Esophageal Neoplasms Esophageal Neoplasms map DI000008386
Eye Abnormalities Eye Abnormalities map DI000011042
Eye Diseases Eye Diseases map DI000007327
Eye Diseases, Hereditary Eye Diseases, Hereditary map DI000009548
Fatty Liver Fatty Liver map DI000007069
Gallbladder Diseases Gallbladder Diseases map DI000010443
Gallbladder Neoplasms Gallbladder Neoplasms map DI000011002
Gastrointestinal Diseases Gastrointestinal Diseases map DI000009332
Gastrointestinal Neoplasms Gastrointestinal Neoplasms map DI000007818
Genetic Diseases, X-Linked Genetic Diseases, X-Linked map DI000008901
Genital Diseases, Male Genital Diseases, Male map DI000009626
Genital Neoplasms, Female Genital Neoplasms, Female map DI000010588
Genital Neoplasms, Male Genital Neoplasms, Male map DI000010116
Glioblastoma Glioblastoma map DI000008598
Glioma Glioma map DI000009750
Goiter Goiter map DI000009456
Graft vs Host Disease Graft vs Host Disease map DI000007246
Gram-Negative Bacterial Infections Gram-Negative Bacterial Infections map DI000009737
Graves Disease Graves Disease map DI000007539
Hamartoma Hamartoma map DI000007095
Head and Neck Neoplasms Head and Neck Neoplasms map DI000009228
Hearing Loss Hearing Loss map DI000010898
Heart Defects, Congenital Heart Defects, Congenital map DI000010300
Heart Diseases Heart Diseases map DI000010412
Heart Failure Heart Failure map DI000007369
Hematologic Diseases Hematologic Diseases map DI000009062
Hemoglobinopathies Hemoglobinopathies map DI000009988
Hemorrhage Hemorrhage map DI000009696
Hemorrhagic Disorders Hemorrhagic Disorders map DI000010441
Hepadnaviridae Infections Hepadnaviridae Infections map DI000009455
Hepatitis Hepatitis map DI000008084
Hepatitis B Hepatitis B map DI000007462
Hepatitis B, Chronic Hepatitis B, Chronic map DI000007485
Hepatitis C Hepatitis C map DI000007463
Hepatitis C, Chronic Hepatitis C, Chronic map DI000009644
Hepatitis, Chronic Hepatitis, Chronic map DI000007263
Hepatitis, Viral, Human Hepatitis, Viral, Human map DI000009687
Hereditary Autoinflammatory Diseases Hereditary Autoinflammatory Diseases map DI000021107
Hereditary Central Nervous System Demyelinating Diseases Hereditary Central Nervous System Demyelinating Diseases map DI000007947
Hereditary Sensory and Motor Neuropathy Hereditary Sensory and Motor Neuropathy map DI000007160
Heredodegenerative Disorders, Nervous System Heredodegenerative Disorders, Nervous System map DI000009162
Herpesviridae Infections Herpesviridae Infections map DI000009435
HIV Infections HIV Infections map DI000010048
Hodgkin Disease Hodgkin Disease map DI000009573
Hypercholesterolemia Hypercholesterolemia map DI000010823
Hyperinsulinism Hyperinsulinism map DI000010696
Hyperlipidemia, Familial Combined Hyperlipidemia, Familial Combined map DI000007454
Hyperlipidemias Hyperlipidemias map DI000010919
Hyperlipoproteinemia Type II Hyperlipoproteinemia Type II map DI000010343
Hyperlipoproteinemias Hyperlipoproteinemias map DI000010197
Hypersensitivity Hypersensitivity map DI000009633
Hypersensitivity, Immediate Hypersensitivity, Immediate map DI000009412
Hypertension Hypertension map DI000007306
Hypertriglyceridemia Hypertriglyceridemia map DI000010933
Hypogonadism Hypogonadism map DI000008670
Hypophosphatemia Hypophosphatemia map DI000010430
Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis map DI000016206
Immune System Diseases Immune System Diseases map DI000010547
Immunologic Deficiency Syndromes Immunologic Deficiency Syndromes map DI000009786
Infection Infection map DI000009248
Inflammation Inflammation map DI000008111
Inflammatory Bowel Diseases Inflammatory Bowel Diseases map DI000008423
Inflammatory Breast Neoplasms Inflammatory Breast Neoplasms map DI000030737
Intellectual Disability Intellectual Disability map DI000007329
Intestinal Diseases Intestinal Diseases map DI000008860
Intestinal Neoplasms Intestinal Neoplasms map DI000008101
Joint Diseases Joint Diseases map DI000007389
Kidney Diseases Kidney Diseases map DI000007750
Kidney Neoplasms Kidney Neoplasms map DI000007626
Laryngeal Neoplasms Laryngeal Neoplasms map DI000009495
Lentivirus Infections Lentivirus Infections map DI000007005
Leukemia Leukemia map DI000010383
Leukemia, B-Cell Leukemia, B-Cell map DI000008025
Leukemia, Erythroblastic, Acute Leukemia, Erythroblastic, Acute map DI000008804
Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Lymphocytic, Chronic, B-Cell map DI000010896
Leukemia, Lymphoid Leukemia, Lymphoid map DI000007106
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Leukemia, Myelogenous, Chronic, BCR-ABL Positive map DI000010662
Leukemia, Myeloid Leukemia, Myeloid map DI000008727
Leukemia, Myeloid, Acute Leukemia, Myeloid, Acute map DI000010922
Leukemia, T-Cell Leukemia, T-Cell map DI000007412
Leukemia-Lymphoma, Adult T-Cell Leukemia-Lymphoma, Adult T-Cell map DI000008845
Leukoencephalopathies Leukoencephalopathies map DI000021099
Lipid Metabolism, Inborn Errors Lipid Metabolism, Inborn Errors map DI000007653
Liposarcoma Liposarcoma map DI000010745
Liver Neoplasms Liver Neoplasms map DI000009581
Lung Diseases Lung Diseases map DI000009013
Lung Diseases, Obstructive Lung Diseases, Obstructive map DI000010603
Lung Neoplasms Lung Neoplasms map DI000008649
Lymphoma Lymphoma map DI000010734
Lymphoma, AIDS-Related Lymphoma, AIDS-Related map DI000009725
Lymphoma, B-Cell Lymphoma, B-Cell map DI000007601
Lymphoma, Large B-Cell, Diffuse Lymphoma, Large B-Cell, Diffuse map DI000008303
Lymphoma, Non-Hodgkin Lymphoma, Non-Hodgkin map DI000009879
Lymphoma, T-Cell Lymphoma, T-Cell map DI000011082
Lymphoproliferative Disorders Lymphoproliferative Disorders map DI000010778
Malabsorption Syndromes Malabsorption Syndromes map DI000008223
Malformations of Cortical Development Malformations of Cortical Development map DI000015716
Melanoma Melanoma map DI000007662
Mental Retardation, X-Linked Mental Retardation, X-Linked map DI000009083
Metabolic Diseases Metabolic Diseases map DI000007418
Metabolism, Inborn Errors Metabolism, Inborn Errors map DI000007224
Mitochondrial Diseases Mitochondrial Diseases map DI000007064
Mitochondrial Encephalomyopathies Mitochondrial Encephalomyopathies map DI000008065
Mitochondrial Myopathies Mitochondrial Myopathies map DI000008494
Motor Neuron Disease Motor Neuron Disease map DI000010812
Mouth Diseases Mouth Diseases map DI000007280
Mouth Neoplasms Mouth Neoplasms map DI000009875
Movement Disorders Movement Disorders map DI000008697
Multiple Myeloma Multiple Myeloma map DI000009753
Multiple Sclerosis Multiple Sclerosis map DI000010313
Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis, Relapsing-Remitting map DI000007385
Muscular Diseases Muscular Diseases map DI000009818
Muscular Dystrophies Muscular Dystrophies map DI000009543
Mycobacterium Infections Mycobacterium Infections map DI000010752
Myeloproliferative Disorders Myeloproliferative Disorders map DI000010990
Myocardial Infarction Myocardial Infarction map DI000010341
Myocardial Ischemia Myocardial Ischemia map DI000010572
Nasopharyngeal Neoplasms Nasopharyngeal Neoplasms map DI000009175
Neoplasms Neoplasms map DI000008074
Neoplasms, Germ Cell and Embryonal Neoplasms, Germ Cell and Embryonal map DI000009775
Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial map DI000008708
Neoplasms, Neuroepithelial Neoplasms, Neuroepithelial map DI000008968
Neoplasms, Squamous Cell Neoplasms, Squamous Cell map DI000010727
Neoplastic Syndromes, Hereditary Neoplastic Syndromes, Hereditary map DI000007843
Nerve Sheath Neoplasms Nerve Sheath Neoplasms map DI000010492
Nervous System Diseases Nervous System Diseases map DI000008969
Neuroblastoma Neuroblastoma map DI000010671
Neurocutaneous Syndromes Neurocutaneous Syndromes map DI000008184
Neurodegenerative Diseases Neurodegenerative Diseases map DI000008925
Neuroectodermal Tumors Neuroectodermal Tumors map DI000010954
Neuroectodermal Tumors, Primitive Neuroectodermal Tumors, Primitive map DI000011056
Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumors, Primitive, Peripheral map DI000010904
Neuroendocrine Tumors Neuroendocrine Tumors map DI000010432
Neuromuscular Diseases Neuromuscular Diseases map DI000009023
Osteoarthritis Osteoarthritis map DI000008631
Osteosarcoma Osteosarcoma map DI000008591
Ovarian Diseases Ovarian Diseases map DI000010219
Ovarian Neoplasms Ovarian Neoplasms map DI000008287
Pancreatic Diseases Pancreatic Diseases map DI000008634
Pancreatic Neoplasms Pancreatic Neoplasms map DI000008861
Paraproteinemias Paraproteinemias map DI000010625
Pharyngeal Neoplasms Pharyngeal Neoplasms map DI000007129
Respiratory Hypersensitivity Respiratory Hypersensitivity map DI000010478
Sarcoma Sarcoma map DI000009187
Skin Abnormalities Skin Abnormalities map DI000010311