About geneXplain
Advancing systems biology through curated knowledge and computational intelligence. geneXplain GmbH develops and maintains scientifically validated biological databases and proprietary upstream analysis tools for academic and industrial research.
What we do
We build and maintain scientifically validated biological knowledge resources and computational tools…
Scientific databases
TRANSFAC, TRANSPATH, PROTEOME and BRENDA — curated resources supporting transcriptional regulation, signaling networks and disease association research.
Software and analysis platform
Proprietary upstream analysis and network modeling tools enabling interpretation of multi-omics data across regulatory layers.
Expertise
geneXplain builds on decades of research in gene regulation and systems biology. Our work combines curated biological knowledge with computational modeling to support robust scientific interpretation.
Scientific foundations
Our expertise originates from academic research in transcriptional regulation and signaling networks. The development of resources such as TRANSFAC and TRANSPATH is rooted in long-term scientific work in regulatory genomics.
Long-term knowledge curation
We maintain and continuously update curated databases integrating experimental evidence from the scientific literature. Structured annotation and quality control are central to our approach.
Computational modeling expertise
Beyond data collection, we develop upstream analysis tools and network-based modeling methods enabling interpretation of multi-omics data across regulatory layers.
Vision
Translating regulatory biology into actionable insight
We believe that understanding complex biological systems requires more than data generation. Regulatory biology provides the mechanistic framework needed to interpret molecular signals in context.
Our vision is to translate curated knowledge and computational modeling into actionable insights that support discovery, decision-making, and therapeutic innovation.
Team
Core team
Dr. Olga Kel-Margoulis
Director Applied Life Science Informatics
Dr. Ines Liebich
Senior Manager Sales & Marketing Product Manager BRENDA
Philip Stegmaier
Manager Software and Technology Development
Scientific advisors
David Cooper
Prof. David N. Cooper is Professor of Human Molecular Genetics at Cardiff University’s School of Medicine, UK. Professor Cooper is the originator of the Human Gene Mutation Database ( http://www.hgmd.org ), a very successful resource both scientifically and commercially, which is used worldwide not only for research purposes but also for counselling in human genetics.
Andreas Dress
Prof. em. Dr. Andreas Dress was Professor of Mathematics at the University of Bielefeld, and between 2005 and 2010 served as Director of the Partner Institute for Computational Biology (PICB) of the Max Planck Society and the Chinese Academy of Sciences in Shanghai. More about his scientific career and interest can be found here .
Partners
geneXplain collaborates with academic institutions, research organizations and industry partners worldwide.
