Classification of Human Transcription Factors - Subfamilies - |
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October 05, 2018 | |||||||||||||||
Display detail: All levels | Superclasses | Classes | Families | Subfamilies | Genera | |||||||||||||||
1 | Superclass: Basic domains | ![]() |
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1.1 | Class: Basic leucine zipper factors (bZIP) | ![]() |
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1.1.1 | Family: Jun-related factors | TGAGTCA | |||||||||||||
1.1.1.1 | Subfamily: Jun factors | TGAGTCA | |||||||||||||
1.1.1.2 | Subfamily: NF-E2-like factors | GCTGAGTCA | |||||||||||||
1.1.1.3 | Subfamily: ATF-2-like factors | TGACGTCA | |||||||||||||
1.1.2 | Family: Fos-related factors | (TGAGTCA) | |||||||||||||
1.1.2.1 | Subfamily: Fos factors | (TGAGTCA) | |||||||||||||
1.1.2.2 | Subfamily: ATF-3-like factors | TGACGTCA | |||||||||||||
1.1.3 | Family: Maf-related factors | TGCTGACTCAGCA | |||||||||||||
1.1.3.1 | Subfamily: Large Maf factors | TGCTGACTCAGCA | |||||||||||||
1.1.3.2 | Subfamily: Small Maf factors | TGCTGACTCAGCA | |||||||||||||
1.1.4 | Family: B-ATF-related factors | TGAGTCA | |||||||||||||
1.1.5 | Family: XBP-1-related factors | GGATGACGTGTACA | |||||||||||||
1.1.6 | Family: ATF-4-related factors | TGACGTCA | |||||||||||||
1.1.7 | Family: CREB-related factors | TGACGTCA | |||||||||||||
1.1.7.1 | Subfamily: CREB-like factors | TGACGTCA | |||||||||||||
1.1.7.2 | Subfamily: CREB-3-like factors | TGACGTCA | |||||||||||||
1.1.7.3 | Subfamily: ATF-6 factors | TGACGTGG | |||||||||||||
1.1.7.4 | Subfamily: CREBZF-like factors | TGACGTCA | |||||||||||||
1.1.7.5 | Subfamily: CREBL2-like factors | TGACGTCA | |||||||||||||
1.1.8 | Family: C/EBP-related | ATTGCGCAAT | |||||||||||||
1.1.8.1 | Subfamily: C/EBP | ATTGCGCAAT | |||||||||||||
1.1.8.2 | Subfamily: PAR factors | TTATGCAA | |||||||||||||
1.1.8.3 | Subfamily: CREBRF-like factors | ||||||||||||||
1.1.0 | Family: ZIP only | ||||||||||||||
1.1.0.1 | Subfamily: TSC22 | ||||||||||||||
1.1.0.2 | Subfamily: UTF | ||||||||||||||
1.2 | Class: Basic helix-loop-helix factors (bHLH) | ![]() |
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1.2.1 | Family: E2A-related factors | CAGGTG | |||||||||||||
1.2.2 | Family: MyoD / ASC-related factors | CAGGTG | |||||||||||||
1.2.2.1 | Subfamily: Myogenic transcription factors | ||||||||||||||
1.2.2.2 | Subfamily: Achaete-Scute-like factors | ||||||||||||||
1.2.3 | Family: Tal-related factors | CAGCTG | |||||||||||||
1.2.3.1 | Subfamily: Tal / HEN-like factors | CAGCTG | |||||||||||||
1.2.3.2 | Subfamily: Twist-like factors | CGTCTG | |||||||||||||
1.2.3.3 | Subfamily: Mesp-like factors | ||||||||||||||
1.2.3.4 | Subfamily: Neurogenin / Atonal-like factors | CAGCTG | |||||||||||||
1.2.3.5 | Subfamily: bHLHa9-like factors | ||||||||||||||
1.2.4 | Family: Hairy-related factors | CACGAG | |||||||||||||
1.2.4.1 | Subfamily: Hairy-like factors | CACGAG | |||||||||||||
1.2.5 | Family: PAS domain factors | CACGC | |||||||||||||
1.2.5.1 | Subfamily: Ahr-like factors | CACGC | |||||||||||||
1.2.5.2 | Subfamily: Arnt-like factors | CACGTG | |||||||||||||
1.2.5.3 | Subfamily: NCoA factors | ||||||||||||||
1.2.5.4 | Subfamily: NPAS-4 | CACGA | |||||||||||||
1.2.5.5 | Subfamily: SOHLH-like factors | ||||||||||||||
1.2.6 | Family: bHLH-ZIP factors | CACATG | |||||||||||||
1.2.6.1 | Subfamily: TFE3-like factors | CACATG | |||||||||||||
1.2.6.2 | Subfamily: USF factors | CACGTG | |||||||||||||
1.2.6.3 | Subfamily: SREBP factors | ATCACCCCAC | |||||||||||||
1.2.6.4 | Subfamily: AP-4 | CAGCTG | |||||||||||||
1.2.6.5 | Subfamily: Myc / Max factors | CACGTG | |||||||||||||
1.2.6.6 | Subfamily: Mondo-like factors | CACGTG | |||||||||||||
1.2.6.7 | Subfamily: Mad1-like factors | CACGTG | |||||||||||||
1.2.6.8 | Subfamily: Mad5-like factors | CACGTG | |||||||||||||
1.2.8 | Family: HLH domain only | ||||||||||||||
1.3 | Class: Basic helix-span-helix factors (bHSH) | ![]() |
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1.3.1 | Family: AP-2 | GCCTGAGGC | |||||||||||||
2 | Superclass: Zinc-coordinating DNA-binding domains | ![]() |
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2.1 | Class: Nuclear receptors with C4 zinc fingers | ![]() |
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2.1.1 | Family: Steroid hormone receptors (NR3) | ||||||||||||||
2.1.1.1 | Subfamily: GR-like receptors (NR3C) | AGAACATGATGTTCT | |||||||||||||
2.1.1.2 | Subfamily: ER-like receptors (NR3A&B) | AGGTCACAGTGACCT | |||||||||||||
2.1.2 | Family: Thyroid hormone receptor-related factors (NR1) | ||||||||||||||
2.1.2.1 | Subfamily: Retinoic acid receptors (NR1B) | TGACCTTTGACCT | |||||||||||||
2.1.2.2 | Subfamily: Thyroid hormone receptors (NR1A) | TGACCTGAAATGACCT | |||||||||||||
2.1.2.3 | Subfamily: Rev-ErbA (NR1D) | TGACCTAGTGACCT | |||||||||||||
2.1.2.4 | Subfamily: Vitamin D receptor (NR1I) | TGACCTTCGTGACCT | |||||||||||||
2.1.2.5 | Subfamily: PPAR (NR1C) | TGACCTTTGACCT | |||||||||||||
2.1.2.6 | Subfamily: ROR (NR1F) | TGACCTACTTAT | |||||||||||||
2.1.2.7 | Subfamily: LXR (NR1H) | TGACCTCTACTGACCT | |||||||||||||
2.1.3 | Family: RXR-related receptors (NR2) | (TGACCT) | |||||||||||||
2.1.3.1 | Subfamily: Retinoid X receptors (NR2B) | (TGACCT) | |||||||||||||
2.1.3.2 | Subfamily: HNF-4 (NR2A) | AGTCCAAAGTTCA | |||||||||||||
2.1.3.3 | Subfamily: Tailless-like receptors (NR2E) | TGACCTTTGACCT | |||||||||||||
2.1.3.4 | Subfamily: Testicular receptors (NR2C) | TGACCTCTGACCT | |||||||||||||
2.1.3.5 | Subfamily: COUP-like receptors (NR2F) | TGACCTTTGACCT | |||||||||||||
2.1.4 | Family: NGFI-B-related receptors (NR4) | TGACCTTT | |||||||||||||
2.1.5 | Family: FTZ-F1-related receptors (NR5) | TGACCTTG | |||||||||||||
2.1.6 | Family: GCNF-related receptors (NR6) | TGAACTTGACTTGA | |||||||||||||
2.1.7 | Family: DAX-related receptors (NR0) | TGACCTT | |||||||||||||
2.2 | Class: Other C4 zinc finger-type factors | ![]() |
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2.2.1 | Family: GATA-type zinc fingers | ||||||||||||||
2.2.1.1 | Subfamily: Two zinc-finger GATA factors | AGATAA | |||||||||||||
2.2.1.2 | Subfamily: Single GATA-type zinc-finger | AGATAA | |||||||||||||
2.3 | Class: C2H2 zinc finger factors | ![]() |
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2.3.1 | Family: Three-zinc finger Krüppel-related factors | ||||||||||||||
2.3.1.1 | Subfamily: Sp1-like factors | GGGGCGGGG | |||||||||||||
2.3.1.2 | Subfamily: Krüppel-like factors | CCACACCCT | |||||||||||||
2.3.1.3 | Subfamily: EGR factors | GCGTGGGCG | |||||||||||||
2.3.2 | Family: Other factors with up to three adjacent zinc fingers | ||||||||||||||
2.3.2.1 | Subfamily: Factors with 2-3 adjacent zinc fingers and a BTB/POZ domain |
TCCTGCTA | |||||||||||||
2.3.2.2 | Subfamily: Factors with 2-3 adjacent zinc fingers and a KRAB domain |
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2.3.2.3 | Subfamily: Factors with 2-3 adjacent zinc fingers and a SCAN domain |
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2.3.2.4 | Subfamily: Other three adjacent zinc finger factors | ||||||||||||||
2.3.3 | Family: More than 3 adjacent zinc finger factors | ||||||||||||||
2.3.3.1 | Subfamily: GLI-like factors | TGGGTGGTC | |||||||||||||
2.3.3.2 | Subfamily: Snail-like factors | CACCTG | |||||||||||||
2.3.3.3 | Subfamily: ZFP91-like factors | ||||||||||||||
2.3.3.4 | Subfamily: ZNF280-like zinc finger factors | ||||||||||||||
2.3.3.5 | Subfamily: ZSCAN5-like zinc finger factors | ||||||||||||||
2.3.3.6 | Subfamily: ZNF75-like zinc finger factors | ||||||||||||||
2.3.3.7 | Subfamily: ZNF705 factors | ||||||||||||||
2.3.3.8 | Subfamily: ZBTB7 factors | GACCCC | |||||||||||||
2.3.3.9 | Subfamily: YY1-like factors | GCCATCTTG | |||||||||||||
2.3.3.10 | Subfamily: ZNF24-like factors | TCAT | |||||||||||||
2.3.3.11 | Subfamily: ZBTB6-like factors | ||||||||||||||
2.3.3.12 | Subfamily: PRDM1-like factors | AAGTGAAAGT | |||||||||||||
2.3.3.13 | Subfamily: ZNF148-like factors | CACCC | |||||||||||||
2.3.3.14 | Subfamily: ZBTB20-like factors | ||||||||||||||
2.3.3.15 | Subfamily: ZNF524-like factors | ||||||||||||||
2.3.3.16 | Subfamily: ZNF238-like factors | AACATCTGGA | |||||||||||||
2.3.3.17 | Subfamily: OVOL-factors | GCGGGGG | |||||||||||||
2.3.3.18 | Subfamily: ZNF56-like factors | ||||||||||||||
2.3.3.19 | Subfamily: ZNF500-like factors | ||||||||||||||
2.3.3.20 | Subfamily: FEZF factors | ||||||||||||||
2.3.3.21 | Subfamily: GFI1 factors | AAATCACAGC | |||||||||||||
2.3.3.22 | Subfamily: BCL6 factors | CTTTCTAGGAAT | |||||||||||||
2.3.3.23 | Subfamily: ZNF212-like factors | ||||||||||||||
2.3.3.24 | Subfamily: MTF1-like factors | TGCACAC | |||||||||||||
2.3.3.25 | Subfamily: PLAG factors | ||||||||||||||
2.3.3.26 | Subfamily: ZKSCAN3-like factors | TGAGGGG | |||||||||||||
2.3.3.27 | Subfamily: ZNF525-like factors | ||||||||||||||
2.3.3.28 | Subfamily: ZNF76-like factors | CCCATCATGCCTTGC | |||||||||||||
2.3.3.29 | Subfamily: ZNF652-like factors | ||||||||||||||
2.3.3.30 | Subfamily: ZNF350-like factors | TGGgttCAGactTTG | |||||||||||||
2.3.3.31 | Subfamily: ZNF642-like factors | ||||||||||||||
2.3.3.32 | Subfamily: ZNF679-like factors | ||||||||||||||
2.3.3.33 | Subfamily: ZNF763-like factors | ||||||||||||||
2.3.3.34 | Subfamily: ZNF3-like factors | ||||||||||||||
2.3.3.35 | Subfamily: ZNF620-like factors | ||||||||||||||
2.3.3.36 | Subfamily: ZNF324 factors | ||||||||||||||
2.3.3.37 | Subfamily: ZNF362-like factors | ||||||||||||||
2.3.3.38 | Subfamily: ZNF282-like factors | TCCACCCC | |||||||||||||
2.3.3.39 | Subfamily: ZNF764-like factors | ||||||||||||||
2.3.3.40 | Subfamily: ZNF177-like factors | ||||||||||||||
2.3.3.41 | Subfamily: ZNF32-like factors | ||||||||||||||
2.3.3.42 | Subfamily: ZNF773-like factors | ||||||||||||||
2.3.3.43 | Subfamily: ZNF558-like factors | ||||||||||||||
2.3.3.44 | Subfamily: ZNF302-like factors | ||||||||||||||
2.3.3.45 | Subfamily: ZNF562-like factors | ||||||||||||||
2.3.3.46 | Subfamily: ZXD-factors | ||||||||||||||
2.3.3.47 | Subfamily: ZNF222-like factors | ||||||||||||||
2.3.3.48 | Subfamily: ZNF736-like factors | ||||||||||||||
2.3.3.49 | Subfamily: ZNF286 factors | ||||||||||||||
2.3.3.50 | Subfamily: CTCF-like factors | ||||||||||||||
2.3.3.51 | Subfamily: ZNF366-like factors | ||||||||||||||
2.3.3.52 | Subfamily: ZNF322-like factors | ||||||||||||||
2.3.3.53 | Subfamily: ZNF548-like factors | ||||||||||||||
2.3.3.54 | Subfamily: ZNF460-like factors | ||||||||||||||
2.3.3.55 | Subfamily: ZNF146-like factors | ||||||||||||||
2.3.3.56 | Subfamily: ZNF214-like factors | ||||||||||||||
2.3.3.57 | Subfamily: ZNF479-like factors | ||||||||||||||
2.3.3.58 | Subfamily: ZNF180-like factors | ||||||||||||||
2.3.3.59 | Subfamily: ZNF100-like factors | ||||||||||||||
2.3.3.60 | Subfamily: ZNF98-like factors | ||||||||||||||
2.3.3.61 | Subfamily: ZNF343-like factors | ||||||||||||||
2.3.3.62 | Subfamily: ZFP2-like factors | ||||||||||||||
2.3.3.63 | Subfamily: ZFP30-like factors | ||||||||||||||
2.3.3.64 | Subfamily: ZNF354A-like factors | ||||||||||||||
2.3.3.65 | Subfamily: ZFX/ZFY factors | AGGCCC | |||||||||||||
2.3.3.66 | Subfamily: ZNF689-like factors | ||||||||||||||
2.3.3.67 | Subfamily: ZFN283-like factors | ||||||||||||||
2.3.3.68 | Subfamily: ZFN81-like factors | ||||||||||||||
2.3.3.69 | Subfamily: ZFN25-like factors | ||||||||||||||
2.3.3.70 | Subfamily: ZFN26-like factors | ||||||||||||||
2.3.3.71 | Subfamily: ZFN300-like factors | ||||||||||||||
2.3.3.72 | Subfamily: ZFN813-like factors | ||||||||||||||
2.3.3.73 | Subfamily: ZNF816A-like factors | ||||||||||||||
2.3.3.74 | Subfamily: ZNF442-like factors | ||||||||||||||
2.3.3.75 | Subfamily: ZNF432-like factors | ||||||||||||||
2.3.3.76 | Subfamily: ZNF665-like factors | ||||||||||||||
2.3.3.77 | Subfamily: ZNF595-like factors | ||||||||||||||
2.3.3.78 | Subfamily: ZNF14-like factors | ||||||||||||||
2.3.3.79 | Subfamily: ZNF841-like factors | ||||||||||||||
2.3.3.80 | Subfamily: ZNF99-like factors | ||||||||||||||
2.3.3.81 | Subfamily: ZNF12-like factors | ||||||||||||||
2.3.3.0 | Subfamily: unclassified | ||||||||||||||
2.3.4 | Family: Factors with multiple dispersed zinc fingers | ||||||||||||||
2.3.4.1 | Subfamily: ZNF417-like factors | ||||||||||||||
2.3.4.2 | Subfamily: ZNF219-like factors | CCCCCA | |||||||||||||
2.3.4.3 | Subfamily: Sal-like factors | ||||||||||||||
2.3.4.4 | Subfamily: Ikaros | TTGGGAAT | |||||||||||||
2.3.4.5 | Subfamily: HIV EP-factors | GGGACTTTCC | |||||||||||||
2.3.4.6 | Subfamily: ZBTB1-like factors | ||||||||||||||
2.3.4.7 | Subfamily: RLF-like factors | ||||||||||||||
2.3.4.8 | Subfamily: MAZ-like factors | GGGGAGGG | |||||||||||||
2.3.4.9 | Subfamily: ZNF532-like factors | ||||||||||||||
2.3.4.10 | Subfamily: ZNF512-factors | ||||||||||||||
2.3.4.11 | Subfamily: ZNF658-factors | ||||||||||||||
2.3.4.12 | Subfamily: ZNF423-like factors | GCACCCAAGGGTGC | |||||||||||||
2.3.4.13 | Subfamily: ZNF639-like factors | ||||||||||||||
2.3.4.14 | Subfamily: Evi-1-like factors | ACAAGATAA | |||||||||||||
2.3.4.15 | Subfamily: BCL11 | ||||||||||||||
2.3.4.16 | Subfamily: Insulinoma-associated proteins | ||||||||||||||
2.3.4.17 | Subfamily: Hypermethylated in Cancer proteins | GGGTGCCCGG | |||||||||||||
2.3.4.18 | Subfamily: ZNF518 | ||||||||||||||
2.3.4.19 | Subfamily: Basonuclin | ||||||||||||||
2.3.4.20 | Subfamily: TRERF1-like factors | ||||||||||||||
2.3.4.21 | Subfamily: HINFP-like factors | CGGACGTT | |||||||||||||
2.3.4.22 | Subfamily: ZNF526-like factors | ||||||||||||||
2.3.4.23 | Subfamily: ZNF319-like factors | ||||||||||||||
2.3.4.24 | Subfamily: ZNF134-like factors | ||||||||||||||
2.3.4.25 | Subfamily: ZNF37A-like factors | ||||||||||||||
2.3.4.0 | Subfamily: unclassified | ||||||||||||||
2.3.5 | Family: BED zinc finger factors | TGTCGCGACA | |||||||||||||
2.4 | Class: C6 zinc cluster factors | ![]() |
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2.5 | Class: DM-type intertwined zinc finger factors | ![]() |
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2.5.1 | Family: DMRT | TGATACATTGTTGC | |||||||||||||
2.6 | Class: CXXC zinc finger factors | ![]() |
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2.6.1 | Family: CpG-binding proteins | ||||||||||||||
2.7 | Class: C2HC zinc finger factors | ![]() |
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2.7.1 | Family: Myelin transcription factor-related proteins | AAGTT | |||||||||||||
2.7.2 | Family: Friend of GATA proteins | ||||||||||||||
2.7.3 | Family: Histone acetyltransferases with C2HC zinc finger | ||||||||||||||
2.7.4 | Family: Lethal(3)malignant brain tumor-related proteins | ||||||||||||||
2.7.5 | Family: LYAR-related proteins | ||||||||||||||
2.8 | Class: C3H zinc finger factors | ![]() |
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2.8.1 | Family: ZC3H8-related factors | ||||||||||||||
2.8.2 | Family: ZGPAT-related factors | ||||||||||||||
2.8.3 | Family: RC3H-related factors | ||||||||||||||
2.8.4 | Family: CNOT4-related factors | ||||||||||||||
2.9 | Class: C2CH THAP-type zinc finger factors | ![]() |
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2.9.1 | Family: THAP-related factors | TTGCCCGTACT | |||||||||||||
3 | Superclass: Helix-turn-helix domains | ![]() |
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3.1 | Class: Homeo domain factors | ![]() |
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3.1.1 | Family: HOX-related factors | ||||||||||||||
3.1.1.1 | Subfamily: HOX1 | TAATTA | |||||||||||||
3.1.1.2 | Subfamily: HOX2 | TAATTA | |||||||||||||
3.1.1.3 | Subfamily: HOX3 | TAATTA | |||||||||||||
3.1.1.4 | Subfamily: HOX4 | TTAATTAA | |||||||||||||
3.1.1.5 | Subfamily: HOX5 | TAATTA | |||||||||||||
3.1.1.6 | Subfamily: HOX6-7 | TAATTA | |||||||||||||
3.1.1.7 | Subfamily: HOX8 | GTAATTA | |||||||||||||
3.1.1.8 | Subfamily: HOX9-13 | TCGTAAA | |||||||||||||
3.1.1.9 | Subfamily: CDX (Caudal type homeobox) | GGTAATAAA | |||||||||||||
3.1.1.10 | Subfamily: EVX (Even-skipped homolog) | CTAATTAG | |||||||||||||
3.1.1.11 | Subfamily: GBX (Gastrulation brain homeobox) | CTAATTAG | |||||||||||||
3.1.1.12 | Subfamily: GSX | TAATTA | |||||||||||||
3.1.1.13 | Subfamily: MNX | ACTAATTA | |||||||||||||
3.1.1.14 | Subfamily: MEOX | TAATTA | |||||||||||||
3.1.1.15 | Subfamily: PDX | TAATTA | |||||||||||||
3.1.2 | Family: NK-related factors | ||||||||||||||
3.1.2.1 | Subfamily: BARHL | AACCAATTA | |||||||||||||
3.1.2.2 | Subfamily: BARX | TAATTA | |||||||||||||
3.1.2.3 | Subfamily: BSX | TAATTA | |||||||||||||
3.1.2.4 | Subfamily: DBX | TTAATTA | |||||||||||||
3.1.2.5 | Subfamily: DLX | TAATTA | |||||||||||||
3.1.2.6 | Subfamily: EMX | CTAATTAG | |||||||||||||
3.1.2.7 | Subfamily: EN (Engrailed-like factors) | CTAATTAG | |||||||||||||
3.1.2.8 | Subfamily: HHEX | ATTAA | |||||||||||||
3.1.2.9 | Subfamily: HLX | TAATTAATTA | |||||||||||||
3.1.2.10 | Subfamily: LBX | TTAATTAA | |||||||||||||
3.1.2.11 | Subfamily: MSX | ACCAATTA | |||||||||||||
3.1.2.12 | Subfamily: NANOG | CCATTT | |||||||||||||
3.1.2.13 | Subfamily: NK-1 | CTAATTAG | |||||||||||||
3.1.2.14 | Subfamily: NK-2.1 | CCACTTGA | |||||||||||||
3.1.2.15 | Subfamily: NK-2.2 | CCACTTGA | |||||||||||||
3.1.2.16 | Subfamily: NK-3 | AAGTACTT | |||||||||||||
3.1.2.17 | Subfamily: NK-4 | CCACTTAA | |||||||||||||
3.1.2.18 | Subfamily: NK-5/HMX | AGCAATTAA | |||||||||||||
3.1.2.19 | Subfamily: NK-6 | AATAATTA | |||||||||||||
3.1.2.20 | Subfamily: NOTO | ||||||||||||||
3.1.2.21 | Subfamily: TLX | AATTAATA | |||||||||||||
3.1.2.22 | Subfamily: VAX | TAATTA | |||||||||||||
3.1.2.23 | Subfamily: VENTX | ||||||||||||||
3.1.3 | Family: Paired-related HD factors | ||||||||||||||
3.1.3.1 | Subfamily: ALX | TTAATTAA | |||||||||||||
3.1.3.2 | Subfamily: ARGFX | ||||||||||||||
3.1.3.3 | Subfamily: ARX | TTAATTAA | |||||||||||||
3.1.3.4 | Subfamily: DMBX | GGATTA | |||||||||||||
3.1.3.5 | Subfamily: DPRX | ||||||||||||||
3.1.3.6 | Subfamily: DRGX | ||||||||||||||
3.1.3.7 | Subfamily: DUX | TCTAATTGAGAATTAC | |||||||||||||
3.1.3.8 | Subfamily: ESX | TTAATTAA | |||||||||||||
3.1.3.9 | Subfamily: GSC | GGATTA | |||||||||||||
3.1.3.10 | Subfamily: HESX | TAATTGAATTA | |||||||||||||
3.1.3.11 | Subfamily: HOPX | ||||||||||||||
3.1.3.12 | Subfamily: ISX | CTAATTAG | |||||||||||||
3.1.3.13 | Subfamily: LEUTX | ||||||||||||||
3.1.3.14 | Subfamily: MIX | ||||||||||||||
3.1.3.15 | Subfamily: NOBOX | CTAATTAG | |||||||||||||
3.1.3.16 | Subfamily: OTP | TTAATTAA | |||||||||||||
3.1.3.17 | Subfamily: OTX | GGGATTAA | |||||||||||||
3.1.3.18 | Subfamily: PHOX | ATAATTAA | |||||||||||||
3.1.3.19 | Subfamily: PITX | GGGATTAA | |||||||||||||
3.1.3.20 | Subfamily: PROP | TTAATTAA | |||||||||||||
3.1.3.21 | Subfamily: PRRX | GCTAATTAGC | |||||||||||||
3.1.3.22 | Subfamily: RAX | CTAATTAG | |||||||||||||
3.1.3.23 | Subfamily: RHOX | CTAATTAG | |||||||||||||
3.1.3.24 | Subfamily: SEBOX | ||||||||||||||
3.1.3.25 | Subfamily: SHOX | TTAATTAA | |||||||||||||
3.1.3.26 | Subfamily: TPRX | ||||||||||||||
3.1.3.27 | Subfamily: UNCX | TTAATTAA | |||||||||||||
3.1.3.28 | Subfamily: VSX | TTAATTAA | |||||||||||||
3.1.4 | Family: TALE-type homeo domain factors | ||||||||||||||
3.1.4.1 | Subfamily: IRX (Iroquois) | TACATGTA | |||||||||||||
3.1.4.2 | Subfamily: MEIS | AGCTGTCAA | |||||||||||||
3.1.4.3 | Subfamily: MKX (Mohawk) | ||||||||||||||
3.1.4.4 | Subfamily: PBX | CATCAAT | |||||||||||||
3.1.4.5 | Subfamily: PKNOX | ACCTGTCAAT | |||||||||||||
3.1.4.6 | Subfamily: TGIF | AGCTGTCAAT | |||||||||||||
3.1.5 | Family: HD-LIM factors | AATTAA; | |||||||||||||
3.1.5.1 | Subfamily: ISL | ATCAATTAA | |||||||||||||
3.1.5.2 | Subfamily: Lhx-1-like factors | TTAATTAA | |||||||||||||
3.1.5.3 | Subfamily: Lhx-2-like factors | TAATTA | |||||||||||||
3.1.5.4 | Subfamily: Lhx-3-like factors | TAATTA | |||||||||||||
3.1.5.5 | Subfamily: Lhx-6-like factors | CTAATTAG | |||||||||||||
3.1.5.6 | Subfamily: Lmx | TTAATTAA | |||||||||||||
3.1.6 | Family: HD-SINE factors | GGTATCA | |||||||||||||
3.1.6.1 | Subfamily: SIX1-like factors | GGGTATCA | |||||||||||||
3.1.6.2 | Subfamily: SIX3-like factors | GGGTATCA | |||||||||||||
3.1.6.3 | Subfamily: SIX4-like factors | GGTGTCA | |||||||||||||
3.1.7 | Family: HD-PROS factors | ||||||||||||||
3.1.8 | Family: HD-ZF factors | ||||||||||||||
3.1.8.1 | Subfamily: ADNP | ||||||||||||||
3.1.8.2 | Subfamily: TSHZ | ||||||||||||||
3.1.8.3 | Subfamily: ZEB | CACCTG | |||||||||||||
3.1.8.4 | Subfamily: ZFHX | ||||||||||||||
3.1.8.5 | Subfamily: ZHX | ATCGTTTT | |||||||||||||
3.1.9 | Family: HD-CUT factors | ||||||||||||||
3.1.9.1 | Subfamily: ONECUT | AAATCAAT | |||||||||||||
3.1.9.2 | Subfamily: CUX | TGATCA | |||||||||||||
3.1.9.3 | Subfamily: SATB | TAATGA | |||||||||||||
3.1.10 | Family: POU domain factors | ||||||||||||||
3.1.10.1 | Subfamily: POU1 (Pit-1-like factors) | TAATTAATTA | |||||||||||||
3.1.10.2 | Subfamily: POU2 (Oct-1/2-like factors) | TATGCAAAT | |||||||||||||
3.1.10.3 | Subfamily: POU3 (Oct-6-like factors) | TAATTAATTA | |||||||||||||
3.1.10.4 | Subfamily: POU4 (Brn-3-like factors) | ATTAATGA | |||||||||||||
3.1.10.5 | Subfamily: POU5 (Oct-3/4-like factors) | ||||||||||||||
3.1.10.6 | Subfamily: POU6 (Brn-5-like factors) | TAATGAG | |||||||||||||
3.1.10.7 | Subfamily: HNF1-like factors | GTTAATGATTAAC | |||||||||||||
3.1.10.8 | Subfamily: HDX-like factors | GAAATCA | |||||||||||||
3.1.11 | Family: PHTF factors | ||||||||||||||
3.2 | Class: Paired box factors | ![]() |
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3.2.1 | Family: Paired plus homeo domain | CTAATTAG | |||||||||||||
3.2.1.1 | Subfamily: PAX-3/7 | CTAATTAG | |||||||||||||
3.2.1.2 | Subfamily: PAX-4/6 | CTAATTAG | |||||||||||||
3.2.2 | Family: Paired domain only | ||||||||||||||
3.2.2.1 | Subfamily: PAX-1/9 (no homeo remnant) | ||||||||||||||
3.2.2.2 | Subfamily: PAX-2-like factors (partial homeobox) | GTCATGCGTGA | |||||||||||||
3.3 | Class: Fork head / winged helix factors | ![]() |
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3.3.1 | Family: Forkhead box (FOX) factors | TGTTT | |||||||||||||
3.3.1.1 | Subfamily: FOXA | TGTTTGTTT | |||||||||||||
3.3.1.2 | Subfamily: FOXB | ||||||||||||||
3.3.1.3 | Subfamily: FOXC | TGTTTATTTAC | |||||||||||||
3.3.1.4 | Subfamily: FOXD | TGTTTACTTAAG | |||||||||||||
3.3.1.5 | Subfamily: FOXE | ||||||||||||||
3.3.1.6 | Subfamily: FOXF | TGTTTATATG | |||||||||||||
3.3.1.7 | Subfamily: FOXG | TTTGTTTTT | |||||||||||||
3.3.1.8 | Subfamily: FOXH | TGTGTATT | |||||||||||||
3.3.1.9 | Subfamily: FOXI | TGTTTGTTTA | |||||||||||||
3.3.1.10 | Subfamily: FOXJ | TGTTTGTTTA | |||||||||||||
3.3.1.11 | Subfamily: FOXK | TTGTTTAC | |||||||||||||
3.3.1.12 | Subfamily: FOXL | TGTTTATGT | |||||||||||||
3.3.1.13 | Subfamily: FOXM | CTGTTTAT | |||||||||||||
3.3.1.14 | Subfamily: FOXN | ||||||||||||||
3.3.1.15 | Subfamily: FOXO | TTGTTTAC | |||||||||||||
3.3.1.16 | Subfamily: FOXP | TTGTTTCA | |||||||||||||
3.3.1.17 | Subfamily: FOXQ | ||||||||||||||
3.3.1.18 | Subfamily: FOXR | ||||||||||||||
3.3.1.19 | Subfamily: FOXS | ||||||||||||||
3.3.2 | Family: E2F-related factors | ||||||||||||||
3.3.2.1 | Subfamily: E2F | ||||||||||||||
3.3.2.2 | Subfamily: Dp-1 | ||||||||||||||
3.3.3 | Family: RFX-related factors | ||||||||||||||
3.4 | Class: Heat shock factors | ![]() |
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3.4.1 | Family: HSF factors | TTCCAGAAGCTTC | |||||||||||||
3.5 | Class: Tryptophan cluster factors | ![]() |
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3.5.1 | Family: Myb/SANT domain factors | ||||||||||||||
3.5.1.1 | Subfamily: Myb-like factors | CAGTTG | |||||||||||||
3.5.1.2 | Subfamily: NCoR-like factors | ||||||||||||||
3.5.1.3 | Subfamily: MIER-like factors | ||||||||||||||
3.5.1.4 | Subfamily: DNAJC-like factors | ||||||||||||||
3.5.1.5 | Subfamily: SMARCA-like factors | ||||||||||||||
3.5.1.6 | Subfamily: TADA2-like factors | ||||||||||||||
3.5.1.7 | Subfamily: DMTF-like factors | CCCGGATGT | |||||||||||||
3.5.1.0 | Subfamily: Other Myb-like factors | ||||||||||||||
3.5.2 | Family: Ets-related factors | GGAAG | |||||||||||||
3.5.2.1 | Subfamily: Ets-like factors | CCGGAAG | |||||||||||||
3.5.2.2 | Subfamily: Elk-like factors | CCGGAAG | |||||||||||||
3.5.2.3 | Subfamily: Elf-1-like factors | CCGGAAAT | |||||||||||||
3.5.2.4 | Subfamily: EHF-like factors | CCGGAAGT | |||||||||||||
3.5.2.5 | Subfamily: Spi-like factors | AGAGGAAG | |||||||||||||
3.5.2.6 | Subfamily: ETV6-like factors | CCCGGAAGT | |||||||||||||
3.5.2.7 | Subfamily: SPDEF-like factors | CCGGATGT | |||||||||||||
3.5.3 | Family: Interferon-regulatory factors | AAGTGAA | |||||||||||||
3.6 | Class: TEA domain factors | ![]() |
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3.6.1 | Family: TEF-1-related factors | CATTCC | |||||||||||||
3.7 | Class: ARID domain factors | ![]() ![]() |
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3.7.1 | Family: ARID-related factors | ||||||||||||||
3.7.1.1 | Subfamily: ARID1 | ||||||||||||||
3.7.1.2 | Subfamily: ARID2 | ||||||||||||||
3.7.1.3 | Subfamily: ARID3 | ||||||||||||||
3.7.1.4 | Subfamily: ARID4 | ||||||||||||||
3.7.1.5 | Subfamily: ARID5 | ||||||||||||||
3.7.1.6 | Subfamily: JARID1 | ||||||||||||||
3.7.1.7 | Subfamily: JARID2 | ||||||||||||||
4 | Superclass: Other all-α-helical DNA-binding domains | ![]() |
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4.1 | Class: High-mobility group (HMG) domain factors | ![]() |
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4.1.1 | Family: SOX-related factors | ACAA | |||||||||||||
4.1.1.1 | Subfamily: Group A | AAACAAA | |||||||||||||
4.1.1.2 | Subfamily: Group B | AACAAAG | |||||||||||||
4.1.1.3 | Subfamily: Group C | AACAAAGG | |||||||||||||
4.1.1.4 | Subfamily: Group D | AACAAT | |||||||||||||
4.1.1.5 | Subfamily: Group E | AAACAAAGG | |||||||||||||
4.1.1.6 | Subfamily: Group F | AACAAT | |||||||||||||
4.1.1.7 | Subfamily: Group G | ||||||||||||||
4.1.1.8 | Subfamily: Group H | GGACAATGG | |||||||||||||
4.1.1.9 | Subfamily: Further Sox-related factors | TTCATTCAA | |||||||||||||
4.1.2 | Family: TOX-related factors | ||||||||||||||
4.1.3 | Family: TCF-7-related factors | TTCAAAG | |||||||||||||
4.1.4 | Family: PBRM1-related factors | ||||||||||||||
4.1.5 | Family: WHSC1-related factors | GGCATTGGAAA | |||||||||||||
4.1.6 | Family: UBF-related factors | ||||||||||||||
4.1.6.1 | Subfamily: UBF-related factors | ||||||||||||||
4.1.6.2 | Subfamily: UBF-like proteins | ||||||||||||||
4.1.7 | Family: TFAM | ||||||||||||||
4.2 | Class: Heteromeric CCAAT-binding factors | ![]() |
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4.2.1 | Family: Heteromeric CCAAT-binding factors | CCAAT | |||||||||||||
5 | Superclass: α-Helices exposed by β-structures | ![]() |
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5.1 | Class: MADS box factors | ![]() |
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5.1.1 | Family: Regulators of differentiation | CTAAAAATAG | |||||||||||||
5.1.1.1 | Subfamily: MEF-2 | CTAAAAATAG | |||||||||||||
5.1.2 | Family: Responders to external signals (SRF/RLM1) | CCATATATGG | |||||||||||||
5.2 | Class: E2-related factors | ||||||||||||||
5.2.1 | Family: E2 | ||||||||||||||
5.3 | Class: SAND domain factors | ![]() |
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5.3.1 | Family: AIRE | ATTGGTTATATTGGTTA | |||||||||||||
5.3.2 | Family: DEAF | TTTCCG | |||||||||||||
5.3.3 | Family: GMEB | CTTCTGTATGAGCGCCAGTAT | |||||||||||||
5.3.3.1 | Subfamily: GMEB | ||||||||||||||
5.3.4 | Family: Sp110 | ||||||||||||||
5.3.5 | Family: Sp140/Sp100 | ||||||||||||||
5.3.5.1 | Subfamily: Sp140-like factors | ||||||||||||||
5.3.5.2 | Subfamily: Sp100 | ||||||||||||||
6 | Superclass: Immunoglobulin fold | ![]() |
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6.1 | Class: Rel homology region (RHR) factors | ![]() |
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6.1.1 | Family: NF-kappaB-related factors | ||||||||||||||
6.1.1.1 | Subfamily: NF-kappaB p50 subunit-like factors | GGGAATTTCC | |||||||||||||
6.1.1.2 | Subfamily: NF-kappaB p65 subunit-like factors | GAAAATTTCC | |||||||||||||
6.1.2 | Family: Ankyrin domain-only factors | ||||||||||||||
6.1.2.1 | Subfamily: IκB-related factors | ||||||||||||||
6.1.2.2 | Subfamily: RelA-associated inhibitor | ||||||||||||||
6.1.3 | Family: NFAT-related factors | ATGGAAA | |||||||||||||
6.1.4 | Family: CSL-related factors | CGTGGGAA | |||||||||||||
6.1.4.1 | Subfamily: M | CGTGGGAA | |||||||||||||
6.1.5 | Family: Early B-Cell Factor-related factors | TCCCTAGGGA | |||||||||||||
6.2 | Class: STAT domain factors | ![]() |
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6.2.1 | Family: STAT factors | TTCCCGGAA | |||||||||||||
6.3 | Class: p53 domain factors | ![]() |
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6.3.1 | Family: p53-related factors | GGACATGCCCGGGCATGTCC | |||||||||||||
6.4 | Class: Runt domain factors | ![]() |
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6.4.1 | Family: Runt-related factors | TGTGGT | |||||||||||||
6.5 | Class: T-Box factors | ![]() |
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6.5.1 | Family: Brachyury-related factors | TCACACCTAGGTGTGAAATT | |||||||||||||
6.5.2 | Family: TBrain-related factors | AGGTGTGAA | |||||||||||||
6.5.3 | Family: TBX1-related factors | ||||||||||||||
6.5.4 | Family: TBX2-related factors | AGGTGTGAG | |||||||||||||
6.5.5 | Family: TBX6-related factors | AATTTCACACCTAGGTGTGAAATT | |||||||||||||
6.6 | Class: NDT80 domain factors | ![]() |
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6.6.1 | Family: Myelin gene regulatory factor-related factors | ||||||||||||||
6.7 | Class: Grainyhead domain factors | ![]() |
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6.7.1 | Family: Grainyhead-related factors | ||||||||||||||
6.7.1.1 | Subfamily: GRH-like proteins | ||||||||||||||
6.7.2 | Family: CP2-related factors | GCACAAACCAG | |||||||||||||
7 | Superclass: β-Hairpin exposed by an α/β-scaffold | ![]() |
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7.1 | Class: SMAD/NF-1 DNA-binding domain factors | ![]() |
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7.1.1 | Family: SMAD factors | GTCTAGAC | |||||||||||||
7.1.1.1 | Subfamily: Regulatory Smads (R-Smad) | ||||||||||||||
7.1.1.2 | Subfamily: Co-activating Smads (Co-Smad) | ||||||||||||||
7.1.1.3 | Subfamily: Repressor-Smads (I-Smad) | ||||||||||||||
7.1.2 | Family: Nuclear factor 1 | TTGGCTATATGCCAA | |||||||||||||
7.2 | Class: GCM domain factors | ![]() |
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7.2.1 | Family: GCM factors | ||||||||||||||
8 | Superclass: β-Sheet binding to DNA | ![]() |
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8.1 | Class: TATA-binding proteins | ![]() |
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8.1.1 | Family: TBP-related factors | TATAAA) | |||||||||||||
8.2 | Class: A.T hook factors | ![]() |
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8.2.1 | Family: HMGA factors | GGAAATT | |||||||||||||
9 | Superclass: β-Barrel DNA-binding domains | ![]() |
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9.1 | Class: Cold-shock domain factors | ![]() |
![]() |
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9.1.1 | Family: Dbp factors | CCAATCAG | |||||||||||||
9.1.1.1 | Subfamily: A (DbpA-like) | ||||||||||||||
9.1.1.2 | Subfamily: B (DbpB/YB-1-like) | ||||||||||||||
9.1.1.3 | Subfamily: C (FRG Y2-like) | ||||||||||||||
0 | Superclass: Yet undefined DNA-binding domains | ![]() |
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0.1 | Class: AXUD/CSRNP domain factors | ![]() |
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0.1.1 | Family: CSRNP factors | AGAGTG | |||||||||||||
0.2 | Class: NonO domain factors | ![]() |
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0.2.1 | Family: NonO-related factors | ||||||||||||||
0.3 | Class: Leucine-rich repeat flightless-interacting proteins | ![]() |
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0.3.1 | Family: LRRFIP factors | AGCCCCCGGCG | |||||||||||||
0.4 | Class: NFX1-type putative zinc finger factors | ![]() |
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0.4.1 | Family: NFX1 | CCTAGCAACAGATG | |||||||||||||
0.5 | Class: GTF2I domain factors | ![]() |
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0.5.1 | Family: TFII-I-related | YCAYY | |||||||||||||
0.6 | Class: CG-1 domain factors | ![]() |
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0.6.1 | Family: CAMTA factors | CGCG | |||||||||||||
0.0 | Class: Uncharacterized | ![]() |
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0.0.1 | Family: Nuclear localized protein 1 | ||||||||||||||
0.0.2 | Family: PHF5 | ||||||||||||||
0.0.3 | Family: RFXANK | CAGTTGCCTAGCAACTA | |||||||||||||
0.0.4 | Family: RFXAP | CAGTTGCCTAGCAACTA | |||||||||||||
0.0.5 | Family: PUR | TGGCCAGGG | |||||||||||||
0.0.6 | Family: NRF | CGCATGCGCA | |||||||||||||
0.0.7 | Family: SPEN factors | ||||||||||||||