Classification of Human Transcription Factors - Families -
October 05, 2018
Display detail:  All levels |  Superclasses |  Classes |  Families |  Subfamilies |  Genera
1	Superclass: Basic domains
	1.1	Class: Basic leucine zipper factors (bZIP)
		1.1.1	Family: Jun-related factors				TGAGTCA
		1.1.2	Family: Fos-related factors				(TGAGTCA)
		1.1.3	Family: Maf-related factors				TGCTGACTCAGCA
		1.1.4	Family: B-ATF-related factors				TGAGTCA
		1.1.5	Family: XBP-1-related factors				GGATGACGTGTACA
		1.1.6	Family: ATF-4-related factors				TGACGTCA
		1.1.7	Family: CREB-related factors				TGACGTCA
		1.1.8	Family: C/EBP-related				ATTGCGCAAT
		1.1.0	Family: ZIP only
	1.2	Class: Basic helix-loop-helix factors (bHLH)
		1.2.1	Family: E2A-related factors				CAGGTG
		1.2.2	Family: MyoD / ASC-related factors				CAGGTG
		1.2.3	Family: Tal-related factors				CAGCTG
		1.2.4	Family: Hairy-related factors				CACGAG
		1.2.5	Family: PAS domain factors				CACGC
		1.2.6	Family: bHLH-ZIP factors				CACATG
		1.2.8	Family: HLH domain only
	1.3	Class: Basic helix-span-helix factors (bHSH)
		1.3.1	Family: AP-2				GCCTGAGGC
2	Superclass: Zinc-coordinating DNA-binding domains
	2.1	Class: Nuclear receptors with C4 zinc fingers
		2.1.1	Family: Steroid hormone receptors (NR3)
		2.1.2	Family: Thyroid hormone receptor-related factors (NR1)
		2.1.3	Family: RXR-related receptors (NR2)				(TGACCT)
		2.1.4	Family: NGFI-B-related receptors (NR4)				TGACCTTT
		2.1.5	Family: FTZ-F1-related receptors (NR5)				TGACCTTG
		2.1.6	Family: GCNF-related receptors (NR6)				TGAACTTGACTTGA
		2.1.7	Family: DAX-related receptors (NR0)				TGACCTT
	2.2	Class: Other C4 zinc finger-type factors
		2.2.1	Family: GATA-type zinc fingers
	2.3	Class: C2H2 zinc finger factors
		2.3.1	Family: Three-zinc finger Krüppel-related factors
		2.3.2	Family: Other factors with up to three adjacent zinc fingers
		2.3.3	Family: More than 3 adjacent zinc finger factors
		2.3.4	Family: Factors with multiple dispersed zinc fingers
		2.3.5	Family: BED zinc finger factors				TGTCGCGACA
	2.4	Class: C6 zinc cluster factors
	2.5	Class: DM-type intertwined zinc finger factors
		2.5.1	Family: DMRT				TGATACATTGTTGC
	2.6	Class: CXXC zinc finger factors
		2.6.1	Family: CpG-binding proteins
	2.7	Class: C2HC zinc finger factors
		2.7.1	Family: Myelin transcription factor-related proteins				AAGTT
		2.7.2	Family: Friend of GATA proteins
		2.7.3	Family: Histone acetyltransferases with C2HC zinc finger
		2.7.4	Family: Lethal(3)malignant brain tumor-related proteins
		2.7.5	Family: LYAR-related proteins
	2.8	Class: C3H zinc finger factors
		2.8.1	Family: ZC3H8-related factors
		2.8.2	Family: ZGPAT-related factors
		2.8.3	Family: RC3H-related factors
		2.8.4	Family: CNOT4-related factors
	2.9	Class: C2CH THAP-type zinc finger factors
		2.9.1	Family: THAP-related factors				TTGCCCGTACT
3	Superclass: Helix-turn-helix domains
	3.1	Class: Homeo domain factors
		3.1.1	Family: HOX-related factors
		3.1.2	Family: NK-related factors
		3.1.3	Family: Paired-related HD factors
		3.1.4	Family: TALE-type homeo domain factors
		3.1.5	Family: HD-LIM factors				AATTAA;
		3.1.6	Family: HD-SINE factors				GGTATCA
		3.1.7	Family: HD-PROS factors
		3.1.8	Family: HD-ZF factors
		3.1.9	Family: HD-CUT factors
		3.1.10	Family: POU domain factors
		3.1.11	Family: PHTF factors
	3.2	Class: Paired box factors
		3.2.1	Family: Paired plus homeo domain				CTAATTAG
		3.2.2	Family: Paired domain only
	3.3	Class: Fork head / winged helix factors
		3.3.1	Family: Forkhead box (FOX) factors				TGTTT
		3.3.2	Family: E2F-related factors
		3.3.3	Family: RFX-related factors
	3.4	Class: Heat shock factors
		3.4.1	Family: HSF factors				TTCCAGAAGCTTC
	3.5	Class: Tryptophan cluster factors
		3.5.1	Family: Myb/SANT domain factors
		3.5.2	Family: Ets-related factors				GGAAG
		3.5.3	Family: Interferon-regulatory factors				AAGTGAA
	3.6	Class: TEA domain factors
		3.6.1	Family: TEF-1-related factors				CATTCC
	3.7	Class: ARID domain factors
		3.7.1	Family: ARID-related factors
4	Superclass: Other all-α-helical DNA-binding domains
	4.1	Class: High-mobility group (HMG) domain factors
		4.1.1	Family: SOX-related factors				ACAA
		4.1.2	Family: TOX-related factors
		4.1.3	Family: TCF-7-related factors				TTCAAAG
		4.1.4	Family: PBRM1-related factors
		4.1.5	Family: WHSC1-related factors				GGCATTGGAAA
		4.1.6	Family: UBF-related factors
		4.1.7	Family: TFAM
	4.2	Class: Heteromeric CCAAT-binding factors
		4.2.1	Family: Heteromeric CCAAT-binding factors				CCAAT
5	Superclass: α-Helices exposed by β-structures
	5.1	Class: MADS box factors
		5.1.1	Family: Regulators of differentiation				CTAAAAATAG
		5.1.2	Family: Responders to external signals (SRF/RLM1)				CCATATATGG
	5.2	Class: E2-related factors
		5.2.1	Family: E2
	5.3	Class: SAND domain factors
		5.3.1	Family: AIRE				ATTGGTTATATTGGTTA
		5.3.2	Family: DEAF				TTTCCG
		5.3.3	Family: GMEB				CTTCTGTATGAGCGCCAGTAT
		5.3.4	Family: Sp110
		5.3.5	Family: Sp140/Sp100
6	Superclass: Immunoglobulin fold
	6.1	Class: Rel homology region (RHR) factors
		6.1.1	Family: NF-kappaB-related factors
		6.1.2	Family: Ankyrin domain-only factors
		6.1.3	Family: NFAT-related factors				ATGGAAA
		6.1.4	Family: CSL-related factors				CGTGGGAA
		6.1.5	Family: Early B-Cell Factor-related factors				TCCCTAGGGA
	6.2	Class: STAT domain factors
		6.2.1	Family: STAT factors				TTCCCGGAA
	6.3	Class: p53 domain factors
		6.3.1	Family: p53-related factors				GGACATGCCCGGGCATGTCC
	6.4	Class: Runt domain factors
		6.4.1	Family: Runt-related factors				TGTGGT
	6.5	Class: T-Box factors
		6.5.1	Family: Brachyury-related factors				TCACACCTAGGTGTGAAATT
		6.5.2	Family: TBrain-related factors				AGGTGTGAA
		6.5.3	Family: TBX1-related factors
		6.5.4	Family: TBX2-related factors				AGGTGTGAG
		6.5.5	Family: TBX6-related factors				AATTTCACACCTAGGTGTGAAATT
	6.6	Class: NDT80 domain factors
		6.6.1	Family: Myelin gene regulatory factor-related factors
	6.7	Class: Grainyhead domain factors
		6.7.1	Family: Grainyhead-related factors
		6.7.2	Family: CP2-related factors				GCACAAACCAG
7	Superclass: β-Hairpin exposed by an α/β-scaffold
	7.1	Class: SMAD/NF-1 DNA-binding domain factors
		7.1.1	Family: SMAD factors				GTCTAGAC
		7.1.2	Family: Nuclear factor 1				TTGGCTATATGCCAA
	7.2	Class: GCM domain factors
		7.2.1	Family: GCM factors
8	Superclass: β-Sheet binding to DNA
	8.1	Class: TATA-binding proteins
		8.1.1	Family: TBP-related factors				TATAAA)
	8.2	Class: A.T hook factors
		8.2.1	Family: HMGA factors				GGAAATT
9	Superclass: β-Barrel DNA-binding domains
	9.1	Class: Cold-shock domain factors
		9.1.1	Family: Dbp factors				CCAATCAG
0	Superclass: Yet undefined DNA-binding domains
	0.1	Class: AXUD/CSRNP domain factors
		0.1.1	Family: CSRNP factors				AGAGTG
	0.2	Class: NonO domain factors
		0.2.1	Family: NonO-related factors
	0.3	Class: Leucine-rich repeat flightless-interacting proteins
		0.3.1	Family: LRRFIP factors				AGCCCCCGGCG
	0.4	Class: NFX1-type putative zinc finger factors
		0.4.1	Family: NFX1				CCTAGCAACAGATG
	0.5	Class: GTF2I domain factors
		0.5.1	Family: TFII-I-related				YCAYY
	0.6	Class: CG-1 domain factors
		0.6.1	Family: CAMTA factors				CGCG
	0.0	Class: Uncharacterized
		0.0.1	Family: Nuclear localized protein 1
		0.0.2	Family: PHF5
		0.0.3	Family: RFXANK				CAGTTGCCTAGCAACTA
		0.0.4	Family: RFXAP				CAGTTGCCTAGCAACTA
		0.0.5	Family: PUR				TGGCCAGGG
		0.0.6	Family: NRF				CGCATGCGCA
		0.0.7	Family: SPEN factors