MATCH Suite
Welcome to MATCH Suite
MATCH Suite is the toolbox of TRANSFAC 2.0, which comprehensively addresses the syntax and semantics of gene regulation and allows you to identify the transcription factors regulating the gene(s) of your interest.
MATCH Suite can be launched on an individual human gene or on a list of human, mouse, or rat genes. Depending on your selection, different analyses will be ran to identify the activation patterns of your input (see Methods documents for functional categorisation-based gene set analysis (human, mouse, rat), gene set tissue expression-based analysis (human), and single gene analysis (human) for further details).
Explore the functional enrichment of your gene set, find only transcription factors (TFs) expressed in the tissue of your interest, or those particular ones that are in the focus of your study, or those that belong to certain functional categories, and much more! You can launch the MATCH Suite by a direct product link from geneXplain databases portal or initiate its analysis from search results in the databases interface. Please refer to the MATCH Suite User guide for further info.
The MATCH Suite automatically generates a comprehensive report on rigorously filtered transcription factors regulating your input gene(s). You can view the tissue expression-based gene set analysis, GO categorisation-based analysis, or single gene analysis example reports generated by the MATCH Suite.
Gene set analysis
The interactive results visualisation section of the MATCH Suite provides you with dynamically filterable tables of the eventually identified TFs and respective matrices (binding models). The genes from the input set are compiled to a dynamically updating table, which demonstrates the regulation of these genes by respective TFs and binding motifs. Interactive genome browser visualisation of the identified sites in the promoters of your input genes is providing intuitive overview of the obtained results and various customisable filters applied.
MATCH Suite tissue expression-based gene set analysis result: Factor Overview table example:
MATCH Suite tissue expression-based gene set analysis result: Factor Pro table example:
MATCH Suite functional categorization-based gene set analysis result: Factor table example:
MATCH Suite gene set analysis result: Matrix table example:
MATCH Suite gene set analysis result: Genes table example:
MATCH Suite tissue expression-based gene set analysis result: Genome browser visualisation example:
Single gene analysis
The interactive results visualisation section of the MATCH Suite provides you with dynamically filterable tables of the eventually identified TFs and respective matrices (binding models). The regulatory regions of the input gene (promoters and enhancers/silencers) are compiled to a dynamically updating table, which demonstrates the regulation of these regions by respective TFs and binding motifs. Interactive genome browser visualisation of the identified sites in the regulatory regions of your input gene is providing intuitive overview of the obtained results and various customisable filters applied.
MATCH Suite single gene analysis result: Factor table example:
MATCH Suite single gene analysis result: Matrix table example:
MATCH Suite single gene analysis result: Regulatory regions table example:
MATCH Suite single gene analysis result: Genome browser visualisation example:
