Why TRANSFAC® License Is Essential
The Foundation for Reliable and Insightful Gene Regulation Research
For more than 35 years, TRANSFAC® has been the gold standard for transcription factor (TF) and regulatory element data. Built through decades of expert manual curation, it remains the most comprehensive and trusted resource for uncovering transcriptional mechanisms and understanding the molecular logic of gene regulation.
Licensing TRANSFAC moves you beyond simple binding-site prediction to causal, systems-level analysis when combined with TRANSPATH® and HumanPSD™, giving you a complete view of how transcription factors, signaling pathways, and diseases are interconnected.
Proven Reliability and Unmatched Curation
35+ years of expert curation ensure reliability unmatched by automated databases
Covers 49,000+ transcription factors and miRNAs, each annotated with functions, disease links, and expression patterns
Every entry—binding sites, TFs, and regulatory associations—is manually verified from primary literature, reducing false positives and guaranteeing reproducible results
Used by 200,000+ researchers and cited in 30,000+ publications, making it the most validated TF resource worldwide.
Quantitative Precision and Data Depth
Over 10,000 Positional Weight Matrices (PWMs) derived from 72,000+ experimentally proven binding sites provide unparalleled accuracy for TFBS prediction
MATCH® tool enables high-precision TFBS prediction, balancing sensitivity and specificity for promoter/enhancer analysis
Integrated with 85.9 million ChIP fragment reports, linking TFs to their genomic binding evidence
Functional classification and annotation of transcription factors across 300+ eukaryotic species, supporting both model and non-model organism studies
Advanced Analytical Power
Upstream Analysis: Integrates TRANSFAC® with TRANSPATH® to trace regulatory cascades upstream of DEGs, identifying key TFs and Master Regulators driving observed gene expression changes
Multi-omics Integration: Combines transcriptomic, genomic, and epigenomic layers for a complete regulatory and signaling landscape
Composite Module Analyst (CMA): Detects cooperative TF binding patterns and composite regulatory modules, revealing synergistic control of gene expression
Translational and Practical Advantages
Biomarker & Drug Target Discovery: Upstream analysis identifies actionable targets, while HumanPSD™ links them to known drugs and clinical trials—accelerating translational insights
No Coding Needed: The geneXplain platform provides an intuitive, click-and-run interface—ideal for biologists seeking powerful bioinformatics without programming
Custom Genome Support: Analyze species-specific or custom genomic data (ChIP-seq, ATAC-seq, promoter sets) using MATCH® and CMA
Included Benefits:
5 hours of expert consultation
100 GB of secure cloud storage
Continuous updates and scientific support
Why a License Matters
A licensed TRANSFAC® package gives you:
- Complete and current datasets unavailable in free versions.
- Regular updates and professional support from the geneXplain team.
- Possible Integration with TRANSPATH® and HumanPSD™ for pathway, disease, and drug insights.
- Reproducible, publication-ready results trusted in academia, pharma, and translational research.
To summarize, licensing TRANSFAC® is not just an upgrade—it’s an investment in scientific accuracy, data integrity, and discovery speed.
It provides the depth, precision, and interpretability required to confidently move from sequence data to biological understanding and translational outcomes.