Master regulators:

The TRANSFAC PATHWAYS package includes the analysis of signal transduction networks (from TRANSPATH) upstream of sets of TFs involved in the expression of certain genes using modern graph algorithm. Key nodes where these pathways converge are considered as master regulators of the process under study.

Activities of transcription factors (TFs, blue circles) are regulated by upstream signaling cascades (components shown as green circles). These converge in potential master regulators of the process under study.