Jayasri Ganta

GeneXplain Consultant

Email:
jayasri.ganta(at)gmail(dot)com

Jayasri Ganta is an experienced professional specialized in scientific content curation, datamining, and biological knowledge base maintenance. She applies her expertise across domains like proteomes, pathways, genetic variation, and biomarkers with the ultimate goal of translating the intricate language of molecular networks into clear, large-scale pathway maps.

Profile

A Biotech/Bioinformatics professional with 23 years of experience in scientific research.
Specialized in generating detailed pathway maps from protein-protein interactions, gene
regulation analysis, post-translational modifications, molecular function studies, disease
association data, and gene expression profiling. Possesses deep knowledge of essential scientific
databases such as PubMed, MeSH, UMLS, NCBI, and Medline.

Professional Experience

Consultant in GeneXplain GmbH

Curation of E. coli Transcription Units (TUs) with references mentioned in RegulonDB.
Worked on mendelian diseases severity associated with disease progression, likelihood of
death and burden of disease etc.
Classification and code diagnoses, symptoms, and procedures of The International Classification of Diseases (ICD-CM). Mapping of ICD 8 codes to ICD 9 and mapping of 15000 ICD-9-CM (USA) and ICD-10-CM (Denmark) diagnosis codes to respective diseases and disorders.
Mapping Drugbank ID to drugs, if no matching Drugbank entry exists, assigning the
corresponding Pubchem ID.

MESH IDs for diseases, Identification of the correct disease term and to add MESH ID
PASS Effects curation, assigned pharmacological effects to disease and all the diseases are mapped according to the MESH database.
Disease Curation, understanding the mechanism of disease by identifying critical components in the gene regulatory network that accounts for a specific disease. The annotations linking the genes and diseases can be categorized into 4 groups as ‘Diagnostic Marker’, ‘Molecular Mechanism’, ‘Negative Correlation’, and ‘Therapeutic Target’.

Signalling pathways from identification of important proteins, curation of their
interactions and post translational modifications. Pathways worked on are:
Pathways related to immune checkpoint proteins like PD-1, PD-L1 and CTLA-4 and
immune response protein PDCD4.
Pathway chains and Protein modification maps for FOXM1, FOXQ1, FOXO1,
FOXO3, FOXO4, FOXP3, FOXC1, FOXA etc.
Pathway chains of GDF15 signalling and activation of GDF15 gene expression.
Gastrin induced activation of NFKBs, ERKs Signaling pathways.
Pathways of MMP7 expression regulated by the Wnt/ β catenin, IL13, IL7, IL1 and EGFR Signalling pathways.
The ANP, BNP, and CNP pathways
Canonical Wnt pathways and Non-canonical Wnt pathways of various WNT family molecules.

Team leader, BIOBASE Knowledge Library (BKL)

Transpath: is a specialized database representing protein-protein interactions, Post-
Translational Modifications (PTMs), and the complete signal flow from ligand binding to
receptor, through to gene transcription. Directly involved in the curation of key pathways,
including Transcription Factors, Neurodegenerative Disease Pathways, Cholesterol Metabolism, TNF, ER-alpha, and EGFR signaling.
Kinome: This is a Pilot Project, Identified 518 kinase proteins. Curated all information related to pathways, Post translational modifications, gene regulation, Molecular function, Regulators, annotations, diseases information and expression etc.

Metanomics: This is a Pilot Project, identified 490 proteins involved for Alzheimer’s.
130 proteins were identified as key molecules for Metanomics. Identified metabolites and
enzymes involved in Creatine synthesis.
SnapiPlus Project: SnapiPlus Project curation involves determining the relationship
between the two proteins and the effect of that relationship on the interacting proteins.
Worked on NFKB and Natural killer cell signaling in this project.

Research associate at Molecular Connections India Pvt.Ltd from

NetPro data is linked to public Ids (like Entrez Gene), facilitating integration of interaction information into proprietary drug discovery databases. The protein-protein interactions in NetProTM are complemented with annotations of the profiled proteins with scientific literature information on a variety of important subjects, including:
Biological Pathways, Diseases implicated, Experimental Methods, Localization, Domain analysis and Go ontology.

Posters and Publications

Protein modifications as determinants for signal transduction specificity in TRANSPATH®

Ines Liebich, Susanne Pistor, Birgit Lewicki-Potapov, Mathias Krull, Nico Voss, Dinesh
Madhyastha, Jayasri Ganta, Karthick Laxman, Mangala K. Sathyamurthy, Olga Kel-Margoulis,
Edgar Wingender BIOBASE GmbH, Halchtersche Straße 33, D-38304 Wolfenbüttel, Germany
Biobase Databases India Private Limited, Bangalore, India Presented at ELSO Dresden,
Germany 2007

The EGFR-family and survival control:

Ines Liebich, Jayasri Ganta, Susanne Pistor, Birgit Lewicki-Potapov, Mathias Krull, Nico Voss, Dinesh Madhyastha, Mangala K. Sathyamurthy, Olga Kel-Margoulis, Edgar Wingender BIOBASE GmbH, Halchtersche Straße 33, D-38304 Wolfenbüttel, Germany Biobase Databases India Private Limited, Bangalore, India Presented at European Conference Center Kirchberg – Luxembourg Apoptosis World 2008

Interlinkage of metabolic and signaling pathways:

Birgit Lewicki-Potapov, Ines Liebich, Susanne Pistor, Mathias Krull, Nico Voss, Balachander Chellamuthu, Jayasri Ganta, Mangala K. Sathyamurthy, Subha Sridhar, Olga Kel-Margoulis, Edgar Wingender BIOBASE GmbH, Halchtersche Straße 33, D 38304 Wolfenbüttel, Germany Biobase Databases India Private Limited, Bangalore, India