When you think of cell signaling, it’s tempting to imagine a single, straight road—but NF-κB runs two. The canonical pathway fires fast to tackle stress and infection, while the non-canonical route, driven by NIK, works more slowly and selectively, shaping immune and developmental responses. TNF superfamily members are the keys…
Discovering Overlapping Mechanisms with Disease Similarity Maps Understanding the molecular relationships between diseases has never been more critical. With the explosion of omics data, we are now able to uncover not only what makes a disease unique — but also what it might share with others. One powerful way to…
We would be happy to share our in-depth white paper detailing the construction of the RT-PCR gene expression panel and its role in identifying patient-specific disease signatures during COPD acute exacerbations. We participated in the FEBS Congress 2025 in Milan. At this event, we presented our latest study on personalized treatment selection for patients undergoing…
Quick Summary Upstream analysis is a bioinformatics method developed by geneXplain to identify master regulators—key transcription factors, kinases, or signaling proteins that drive observed gene expression changes in diseases like cancer. Unlike traditional enrichment analyses that show downstream effects, upstream analysis works backwards from differentially expressed genes (DEGs) to reveal…
End of content
End of content