A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol
A collaborative project funded by the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 305707, research area FP7-HEALTH-2012-INNOVATION-1, topic HEALTH.2012.2.1.2-2: Systems medicine: Applying systems biology approaches for understanding multifactorial human diseases and their comorbidities
- build a computational model for analyzing the kinetics of plasma lipids, lipoproteins and their interactions with glucose metabolism;
- apply the iterative systems biology cycle for calibrating, validating and improving the computational model in dedicated studies in mice;
- build, calibrate and validate the computational model for use in humans;
- analyze – based on model and experimental data – which processes in the murine metabolic network regulatethe physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interact;
- analyze – based on model and experimental data – which processes in the human metabolic network regulatethe physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interact;
- use the human model to identify network-based drug targets aimed at restoring the metabolic dyslipidemia and glycemic control in patients with MetS and associated comorbidities.
The 60-months project RESOLVE will result into a novel strategy for development of therapeutic strategies for MetS patients with T2DM, NAFLD or CVD.
January 23rd: Kick-off meeting in Lille
The project is coordinated by Prof. Dr. Albert K. Groen, University Medical Center, Groningen, The Netherlands.
The 13 participants of the consortium are from 8 European countries.
January 1st, 2013 – December 31st, 2017