TRANSFAC® Diseases

Online academic lab license for 4 seats

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TRANSFAC Diseases includes the full functionality of TRANSFAC Pathways with its renowned manually curated database of eukaryotic transcription factors, their genomic binding sites and DNA-binding profiles, together with the comprehensive knowledge base on signal transduction and metabolic pathways, as well as the Gene-Disease-Drug-Clinical Trial assignments, disease biomarkers, drug targets, and drug-disease approval status.

  • Predict transcription factor binding sites and their combinations on a genomic scale using the biggest collection of positional weight matrices (over 10,000) with in-built Machine Learning and Artificial Intelligence methods.
  • Access the biggest knowledge base on transcription factors, their experimentally characterized binding sites and ChIP experiments, as well as genes regulated by them, their promoters, enhancers and silencers.
  • Enjoy the full range of abilities for promoter analysis addressing the needs of users with various backgrounds: from customized analysis pipelines intended for core bioinformaticians to fully automatized no-coding solutions for bench biologists and biomedical researchers.
  • Perform your multi-omics data analysis in the geneXplain platform integrated with TRANSFAC subscription (extra workspace can be purchased on demand).
  • Browse information on signal transduction and metabolic pathways, individual reactions with experimental details, protein-protein interactions and post-translational modifications.
  • Predict potential pathways targeting the genes of your interest.
  • Build customized regulatory and metabolic networks.
  • Apply integrated pathway visualization and modification tool.
  • Perform integrated promoter and pathway analysis for identification of prospective drug targets and disease biomarkers.
  • Automatically process multi-omics raw patient data and identify prospective drug targets and treatments predicted to be effective for the studied clinical case.
  • Run complicated omics data processing pipelines from just several clicks in a user-friendly interface without bioinformatics skills.

What you will get

A comprehensive solution for gene regulation analysis covering more than 300 species, with a focus on Human, Mouse, Rat, Drosophila, Zebrafish, Yeast, and plants where emphasis is on Arabidopsis, Soybean and Rice.

Access to the unique MATCH Suite tool (Human only) for identification of transcription factors regulating the human gene(s) of your interest in the specified conditions.

Interactive search engine providing access to world’s largest manually curated encyclopedia of transcriptional regulation, as well as comprehensive knowledge base on signal transduction and metabolic pathways, individual reactions with experimental details, protein-protein interactions and post-translational modifications, together with the information on Gene-Disease-Drug-Clinical Trial assignments, disease biomarkers, drug targets, and drug-disease approval status.

Upstream Analysis – integrated promoter and pathway analysis.

Deep understanding of molecular mechanisms underlying the studied pathology.

Prospective treatments suggestions covering both: known and repurposed drugs for the studied pathology in complicated clinical cases where no conventional therapies are effective.

Automatically generated comprehensive report fully explaining the performed analysis and the obtained results.

Molecular Tumor Board report based on patient’s genomics data supported for a number of neoplasm diseases.

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