8.1 Class: Cold-shock domain factors (TBP)
Description: Class description: A 10-stranded, anti-parallel beta-sheet forms a quasi-symmetric saddle-like structure, where the convex side is backed by four alpha-helices and the concave side exerts mostly hydrophobic interactions with the minor groove of the TATA-box. Binding of TBP imposes a significant kink of the DNA double helix axis. (PMID 10617571, and references cited therein)
Aligned domain sequences: Alignment of TBP sequences
Download fasta file of whole DBDs or of repeats.
Logo plot:
Blue: basic residues (KRH); red: acidic residues (DE); purple: amides (QN); black: hydrophobic residues (AVLIPWFM); green: polar (CSTYG) (http://weblogo.berkeley.edu/)