6.5 Class: T-box factors (T-box)
Description: TRANSFAC® class description C0044: The T domain has originally been discovered in Brachyury (T) the founder member of the T-box family. It encodes a DNA binding domain of about 180 amino acids. X-ray analysis of the T domain showed that it binds as a dimer to a 20 nucleotide partially palindromic sequence. A new type of specific DNA contact is seen, in which a carboxy-terminal helix is deeply embedded into an enlarged minor groove without bending the DNA.
Aligned domain sequences: Alignment of T-box domains
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Logo plot:
Blue: basic residues (KRH); red: acidic residues (DE); purple: amides (QN); black: hydrophobic residues (AVLIPWFM); green: polar (CSTYG) (http://weblogo.berkeley.edu/)