6.2 Class: STAT domain factors (STAT)
Description: Class description: STAT proteins bind to DNA as dimers. The DNA-contacting interface is organized by an eight-stranded beta-barrel, N-terminally preceded by a four-helix bundle and C-terminally followed by a mostly alpha-helical connector region. The residues that bind to the major groove of the DNA are mostly exposed by loops connecting the beta-strands of the beta-barrel and the one linking the beta-barrel and the first helix of the 'connector' region. The STAT dimer nearly completely embraces the DNA double helix, compared with a 'pair of pliers' (PMID 9671298), with the DNA-binding interface as jaws and the four-helix bundles as handles. Bound by STAT, the DNA undergoes a moderate bending of about 40 degrees. (PMID 9671298)
Aligned domain sequences: Alignment of STAT domains
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Logo plot:
Blue: basic residues (KRH); red: acidic residues (DE); purple: amides (QN); black: hydrophobic residues (AVLIPWFM); green: polar (CSTYG) (http://weblogo.berkeley.edu/)