Synonyms:
LFA-1; CD11a/CD18; heterodimer (integrin-alphaL)&(beta2); Lymphocyte function-associated antigen-1
Description:
beta2-integrin: Integrin beta 2, acts in cell adhesion and immunity, upregulated in arthritis, diabetes, HIV, sclerosis, ischemic attack, Crohn disease, psoriasis, melanoma, and several cancers; gene mutation correlates with leukocyte-adhesion deficiency syndrome
alphaL-integrin: Integrin alpha L, interacts with cell adhesion molecule, acts in leukocyte cell adhesion, T cell homing, and immunity, aberrantly expressed in AIDS, rheumatoid arthritis, Crohn disease, multiple sclerosis, ischemic stroke, attacks, and many neoplasms
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