Synonyms:
PDGFR; heterodimer (PDGFRalpha)&(PDGFRbeta)
Description:
PDGFRbeta: Platelet-derived growth factor receptor beta polypeptide, exhibits kinase activity, acts in activation of MAPK activity and chemotaxis, upregulated in breast and several other neoplasms; gene translocations are associated with myeloproliferative disorders
PDGFRalpha: Platelet-derived growth factor receptor alpha, a tyrosine kinase, acts in lung development and cell migration, increased expression correlates with glioma, gastrointestinal, and colorectal carcinomas; gene mutation causes piebaldism and spinal dysraphism
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