Synonyms:
IL-2R (high affinity); heterodimer (gamma-c)&(IL-2Rbeta)
Description:
IL-2Rbeta: Interleukin 2 receptor beta, acts in cytokine-mediated signaling, chemotaxis, natural killer cell mediated cytotoxicity, and immunity, stimulates TNF-alpha production and T-cell proliferation, upregulated in lung cancer and downregulated in SCID
gamma-c: Interleukin 2 receptor gamma, acts in JAK-STAT cascade, antiapoptosis, and hemopoiesis, protein is upregulated in colitis, multiple sclerosis, encephalitis, and Crohn disease; gene mutations are associated with X linked severe combined immunodeficiency
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