Synonyms:
IL-4R type l; heterodimer (alpha)&(gamma)
Description:
IL-4Ralpha: Interleukin 4 receptor, acts in antiapoptosis, MAPK inactivation, and immune response; gene polymorphism is associated with asthma, osteoarthritis, type 1 diabetes, renal cell carcinoma, B cell lymphoma, rheumatoid arthritis, eczema, and cervical cancer
gamma-c: Interleukin 2 receptor gamma, acts in JAK-STAT cascade, antiapoptosis, and hemopoiesis, protein is upregulated in colitis, multiple sclerosis, encephalitis, and Crohn disease; gene mutations are associated with X linked severe combined immunodeficiency
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