SysmedIBD– Systems medicine of chronic inflammatory bowel disease
A collaborative project funded by the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 305564, research area FP7-HEALTH-2012-INNOVATION-1, topic HEALTH.2012.2.1.2-2: Systems medicine: Applying systems biology approaches for understanding multifactorial human diseases and their comorbidities.
Gaining control of the oscillation of biological pathways may provide new possibilities to influence biological processes like inflammation. Hence, we will search (assisted by the models and databases developed) for small molecules interfering with the NF-kappaB oscillation and validate selected candidates in experimental systems. Owing to its highly focused system biological approach, the project will generate substantial insights into key mechanisms underlying IBD.
GeneXplain will be involved in the dynamic simulation of the oscillating processed described above, and in the identification of suitable targets and drug candidates, which will then be experimentally validated by the partners.