Explain Inhalation Toxicity-2
Animal-free mechanism-based toxicity testing – predict toxicity after repeated dose inhalation exposure by using a read across approach.
A collaborative project funded by the German Federal Ministry of Education and Research (BMBF) in the funding program
“e:ToP – Innovative Toxikologie zur Reduzierung von Tierversuchen”
- The uptake of compounds after inhalation exposure will be estimated by physiological pharmacokinetic modeling and QSAR models.
- The onset of gene changes and miRNA regulation, by dose dependent testing, will be investigated to better differentiate between group-specific changes and general stress responses related to high dosing.
- We will further generate and use master pathways per group to differentiate AOP related changes from general cellular stress responses.
- An IATA will be developed, which allows to predict the toxicity of an untested compound in a read across context based on the generated data.
The project is coordinated by Dr. Sylvia Escher, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) in Hannover.
The 5 participants of the consortium are from Hannover, Göttingen, Emden, and Wolfenbüttel.